Design of an engineered ACE2 as a novel therapeutics against COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Theoretical Biology"
DOI: 10.1016/j.jtbi.2020.110425
Abstract: Abstract The interaction between the angiotensin-converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of the spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a pivotal role in virus entry into… read more here.
Keywords: engineered ace2; ace2; interaction; sars cov ... See more keywords
Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24013-y
Abstract: SARS-CoV-2 has mutated during the global pandemic leading to viral adaptation to medications and vaccinations. Here we describe an engineered human virus receptor, ACE2, by mutagenesis and screening for binding to the receptor binding domain… read more here.
Keywords: escape; ace2 receptor; receptor therapy; sars cov ... See more keywords
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Science translational medicine"
DOI: 10.1126/scitranslmed.abn7737
Abstract: The Omicron (B.1.1.529) SARS-CoV-2 variant contains an unusually high number of mutations in the spike protein, raising concerns of escape from vaccines, convalescent serum and therapeutic drugs. Here we analyzed the degree to which Omicron… read more here.
Keywords: omicron; decoy neutralizes; infection; engineered ace2 ... See more keywords
Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.889372
Abstract: Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS-CoV-2 neutralization and Fc-effector functions of ACE2-Fc decoy proteins, formatted with or… read more here.
Keywords: ace2 potent; neutralization; potent multifunctional; multifunctional agent ... See more keywords