Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06271-5
Abstract: Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other… read more here.
Keywords: engineered antibody; ultrasmall targeted; targeted nanoparticles; her2 ... See more keywords
An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71519-4
Abstract: V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and T… read more here.
Keywords: antibody; binds distinct; distinct epitope; vista ... See more keywords
Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02487-2
Abstract: Protein-based targeting reagents, such as antibodies and non-antibody scaffold proteins, are rapidly inactivated in the upper gastrointestinal (GI) tract. Hydrochloric acid in gastric juice denatures proteins and activates pepsin, concentrations of which reach 1 mg/mL in… read more here.
Keywords: pepsin; antibody; hydrochloric acid; antibody mimetics ... See more keywords