Minicircle DNA-Engineered CAR T Cells Suppressed Tumor Growth in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-0204
Abstract: Viral-based chimeric antigen receptor-engineered T (CAR T)–cell manufacturing has potential safety risks and relatively high costs. The nonviral minicircle DNA (mcDNA) is safer for patients, cheaper to produce, and may be a more suitable technique… read more here.
Keywords: car cells; dna engineered; minicircle dna; engineered car ... See more keywords
Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1121030
Abstract: Adoptive cell therapy (ACT) has seen a steep rise of new therapeutic approaches in its immune-oncology pipeline over the last years. This is in great part due to the recent approvals of chimeric antigen receptor… read more here.
Keywords: cell; tcr cells; engineered car; car ... See more keywords