Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases.
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DOI: 10.1021/jacs.9b02700
Abstract: We report the development of engineered myoglobin biocatalysts for executing asymmetric intramolecular cyclopropanations resulting in cyclopropane-fused γ-lactones, which are key motifs found in many bioactive molecules. Using this strategy, a broad range of allyl diazoacetate… read more here.
Keywords: cyclopropanation; cyclopropanation enabled; intramolecular cyclopropanation; stereodivergent intramolecular ... See more keywords