Crossbow Bioreactors for Studying the Effects of Time‐Varying Mechanical Preload and Afterload on Engineered Cardiac Tissues
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202519601
Abstract: Mechanical loading plays a critical role in heart development and function, with cardiac preload (tissue stretch during chamber filling) and afterload (resistance against which the heart works to eject blood) potentially playing distinct roles in… read more here.
Keywords: preload afterload; cardiac tissues; engineered cardiac; culture ... See more keywords
Chemically defined production of engineered cardiac tissue microspheres from hydrogel‐encapsulated pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28818
Abstract: Chemically defined, suspension culture conditions are a key requirement in realizing clinical translation of engineered cardiac tissues (ECTs). Building on our previous work producing functional ECT microspheres through differentiation of biomaterial encapsulated human induced pluripotent… read more here.
Keywords: differentiation; chemically defined; ect microspheres; stem ... See more keywords
Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0668-1_13
Abstract: Engineered cardiac tissues hold tremendous promise for in vitro drug discovery, studies of heart development and disease, and therapeutic applications. Here, we describe a versatile "frame-hydrogel" methodology to generate engineered cardiac tissues with highly mature… read more here.
Keywords: methodology; hydrogel methodology; frame hydrogel; engineered cardiac ... See more keywords
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0830-2_10
Abstract: The delivery of cells into damaged myocardium induces limited cardiac regeneration due to extensive cell death. In an effort to limit cell death, our lab formulates three-dimensional matrices as a delivery system for cell therapy.… read more here.
Keywords: human induced; engineered cardiac; cardiac tissues; pluripotent stem ... See more keywords
Bioprinting Approaches to Engineering Vascularized 3D Cardiac Tissues
Sign Up to like & getrecommendations! Published in 2019 at "Current Cardiology Reports"
DOI: 10.1007/s11886-019-1179-8
Abstract: 3D bioprinting technologies hold significant promise for the generation of engineered cardiac tissue and translational applications in medicine. To generate a clinically relevant sized tissue, the provisioning of a perfusable vascular network that provides nutrients… read more here.
Keywords: approaches engineering; engineered cardiac; tissue; cardiac tissues ... See more keywords
Nanoparticle-Based Hybrid Scaffolds for Deciphering the Role of Multi-Modal Cues in Cardiac Tissue Engineering.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b03050
Abstract: Myocardial microenvironment plays a decisive role in guiding the function and fate of cardiomyocytes and engineering this extracellular niche holds great promises for cardiac tissue regeneration. Platforms utilizing hybrid hydrogels containing various types of conductive… read more here.
Keywords: hybrid scaffolds; gelma; cardiac tissue; engineered cardiac ... See more keywords
Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0320-y
Abstract: Cadmium (Cd) is a nonessential heavy metal and a prevalent environmental toxin that has been shown to induce significant cardiomyocyte apoptosis in neonatal murine engineered cardiac tissues (ECTs). In contrast, zinc (Zn) is a potent… read more here.
Keywords: neonatal murine; murine engineered; engineered cardiac; toxicity ... See more keywords
Neonatal Murine Engineered Cardiac Tissue Toxicology Model: Impact of Metallothionein Overexpression on Cadmium-Induced Injury
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy177
Abstract: Engineered cardiac tissues (ECTs) serve as robust in vitro models to study human cardiac diseases including cardiac toxicity assays due to rapid structural and functional maturation and the ability to vary ECT composition. Metallothionein (MT)… read more here.
Keywords: overexpression; neonatal murine; engineered cardiac; toxicity ... See more keywords
Nonclinical evaluation of chronic cardiac contractility modulation on 3D human engineered cardiac tissues
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cardiovascular Electrophysiology"
DOI: 10.1111/jce.16222
Abstract: Cardiac contractility modulation (CCM) is a medical device‐based therapy delivering non‐excitatory electrical stimulations to the heart to enhance cardiac function in heart failure (HF) patients. The lack of human in vitro tools to assess CCM… read more here.
Keywords: contractility modulation; engineered cardiac; cardiac tissues; cardiac contractility ... See more keywords
Skeletal Extracellular Matrix Supports Cardiac Differentiation of Embryonic Stem Cells: a Potential Scaffold for Engineered Cardiac Tissue
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000486813
Abstract: Background/Aims: Decellularized cardiac extracellular matrix (cECM) has been widely considered as an attractive scaffold for engineered cardiac tissue (ECT), however, its application is limited by immunogenicity and shortage of organ donation. Skeletal ECM (sECM) is… read more here.
Keywords: cardiac tissue; extracellular matrix; engineered cardiac; tissue ... See more keywords
High throughput screening system for engineered cardiac tissues
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1177688
Abstract: Introduction: Three dimensional engineered cardiac tissues (3D ECTs) have become indispensable as in vitro models to assess drug cardiotoxicity, a leading cause of failure in pharmaceutical development. A current bottleneck is the relatively low throughput… read more here.
Keywords: system; contractile force; engineered cardiac; throughput screening ... See more keywords