Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0668-1_13
Abstract: Engineered cardiac tissues hold tremendous promise for in vitro drug discovery, studies of heart development and disease, and therapeutic applications. Here, we describe a versatile "frame-hydrogel" methodology to generate engineered cardiac tissues with highly mature… read more here.
Keywords: methodology; hydrogel methodology; frame hydrogel; engineered cardiac ... See more keywords
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0830-2_10
Abstract: The delivery of cells into damaged myocardium induces limited cardiac regeneration due to extensive cell death. In an effort to limit cell death, our lab formulates three-dimensional matrices as a delivery system for cell therapy.… read more here.
Keywords: human induced; engineered cardiac; cardiac tissues; pluripotent stem ... See more keywords
Bioprinting Approaches to Engineering Vascularized 3D Cardiac Tissues
Sign Up to like & getrecommendations! Published in 2019 at "Current Cardiology Reports"
DOI: 10.1007/s11886-019-1179-8
Abstract: 3D bioprinting technologies hold significant promise for the generation of engineered cardiac tissue and translational applications in medicine. To generate a clinically relevant sized tissue, the provisioning of a perfusable vascular network that provides nutrients… read more here.
Keywords: approaches engineering; engineered cardiac; tissue; cardiac tissues ... See more keywords
Nanoparticle-Based Hybrid Scaffolds for Deciphering the Role of Multi-Modal Cues in Cardiac Tissue Engineering.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b03050
Abstract: Myocardial microenvironment plays a decisive role in guiding the function and fate of cardiomyocytes and engineering this extracellular niche holds great promises for cardiac tissue regeneration. Platforms utilizing hybrid hydrogels containing various types of conductive… read more here.
Keywords: hybrid scaffolds; gelma; cardiac tissue; engineered cardiac ... See more keywords
Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0320-y
Abstract: Cadmium (Cd) is a nonessential heavy metal and a prevalent environmental toxin that has been shown to induce significant cardiomyocyte apoptosis in neonatal murine engineered cardiac tissues (ECTs). In contrast, zinc (Zn) is a potent… read more here.
Keywords: neonatal murine; murine engineered; engineered cardiac; toxicity ... See more keywords
Neonatal Murine Engineered Cardiac Tissue Toxicology Model: Impact of Metallothionein Overexpression on Cadmium-Induced Injury
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy177
Abstract: Engineered cardiac tissues (ECTs) serve as robust in vitro models to study human cardiac diseases including cardiac toxicity assays due to rapid structural and functional maturation and the ability to vary ECT composition. Metallothionein (MT)… read more here.
Keywords: overexpression; neonatal murine; engineered cardiac; toxicity ... See more keywords
Skeletal Extracellular Matrix Supports Cardiac Differentiation of Embryonic Stem Cells: a Potential Scaffold for Engineered Cardiac Tissue
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000486813
Abstract: Background/Aims: Decellularized cardiac extracellular matrix (cECM) has been widely considered as an attractive scaffold for engineered cardiac tissue (ECT), however, its application is limited by immunogenicity and shortage of organ donation. Skeletal ECM (sECM) is… read more here.
Keywords: cardiac tissue; extracellular matrix; engineered cardiac; tissue ... See more keywords
High throughput screening system for engineered cardiac tissues
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1177688
Abstract: Introduction: Three dimensional engineered cardiac tissues (3D ECTs) have become indispensable as in vitro models to assess drug cardiotoxicity, a leading cause of failure in pharmaceutical development. A current bottleneck is the relatively low throughput… read more here.
Keywords: system; contractile force; engineered cardiac; throughput screening ... See more keywords
Engineering and Assessing Cardiac Tissue Complexity
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22031479
Abstract: Cardiac tissue engineering is very much in a current focus of regenerative medicine research as it represents a promising strategy for cardiac disease modelling, cardiotoxicity testing and cardiovascular repair. Advances in this field over the… read more here.
Keywords: cardiac tissue; engineered cardiac; tissue; tissue constructs ... See more keywords
Wet-Spun Polycaprolactone Scaffolds Provide Customizable Anisotropic Viscoelastic Mechanics for Engineered Cardiac Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14214571
Abstract: Myocardial infarction is a leading cause of death worldwide and has severe consequences including irreversible damage to the myocardium, which can lead to heart failure. Cardiac tissue engineering aims to re-engineer the infarcted myocardium using… read more here.
Keywords: spun polycaprolactone; wet spun; engineered cardiac; mechanics ... See more keywords