Bevacizumab-Laden Nanofibers Simulating an Antiangiogenic Niche to Improve the Submuscular Stability of Stem Cell Engineered Cartilage.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201874
Abstract: Bone marrow stem cells (BMSCs) engineered cartilage (BEC) is prone to endochondral ossification in a submuscular environment due to the process of vascular infiltration, which limits its application in repairing tracheal cartilage defects. Bevacizumab, an… read more here.
Keywords: bevnf; engineered cartilage; cartilage; bevacizumab ... See more keywords
Human chondrocyte migration behaviour to guide the development of engineered cartilage
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.1988
Abstract: Tissue‐engineering techniques have been successful in developing cartilage‐like tissues in vitro using cells from animal sources. The successful translation of these strategies to the clinic will likely require cell expansion to achieve sufficient cell numbers.… read more here.
Keywords: engineered cartilage; migration; human chondrocyte; culture ... See more keywords
A mathematical model of tissue-engineered cartilage development under cyclic compressive loading
Sign Up to like & getrecommendations! Published in 2017 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-016-0843-9
Abstract: In this work a coupled model of solute transport and uptake, cell proliferation, extracellular matrix synthesis and remodeling of mechanical properties accounting for the impact of mechanical loading is presented as an advancement of a… read more here.
Keywords: model; engineered cartilage; coupled model; tissue engineered ... See more keywords
Deep learning enables the automation of grading histological tissue engineered cartilage images for quality control standardization.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2020.12.018
Abstract: OBJECTIVE To automate the grading of histological images of engineered cartilage tissues using deep learning. METHODS Cartilaginous tissues were engineered from various cell sources. Safranin O and fast green stained histological images of the tissues… read more here.
Keywords: engineered cartilage; quality; grading histological; deep learning ... See more keywords
DMOG Negatively Impacts Tissue Engineered Cartilage Development.
Sign Up to like & getrecommendations! Published in 2020 at "Cartilage"
DOI: 10.1177/1947603520967060
Abstract: OBJECTIVE Articular cartilage exists in a hypoxic environment, which motivates the use of hypoxia-simulating chemical agents to improve matrix production in cartilage tissue engineering. The aim of this study was to investigate whether dimethyloxalylglycine (DMOG),… read more here.
Keywords: engineered cartilage; matrix; dmog; tissue engineered ... See more keywords
An Injectable Platform of Engineered Cartilage Gel and Gelatin Methacrylate to Promote Cartilage Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.884036
Abstract: Cell–hydrogel constructs are frequently used as injectable platforms for irregular cartilage regeneration. However, cell–hydrogel constructs have obvious disadvantages, such as long culture times, high probability of infection, and poor cartilage formation capacity, significantly limiting their… read more here.
Keywords: gelma; injectable platform; engineered cartilage; cartilage ... See more keywords
Hyaluronic Acid Influence on Normal and Osteoarthritic Tissue-Engineered Cartilage
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19051519
Abstract: The aim of this study is to identify gene expression profiles associated with hyaluronic acid (HA) treatment of normal and osteoarthritis (OA)-like tissue-engineered cartilage. 3D cartilage micromasses were treated with tumour necrosis factor-α (TNF-α) (OA-inducer)… read more here.
Keywords: engineered cartilage; tissue engineered; hyaluronic acid; influence ... See more keywords