Articles with "engineered cell" as a keyword



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Engineered Cell-Membrane-Coated Nanoparticles Directly Present Tumor Antigens to Promote Anticancer Immunity.

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Published in 2020 at "Advanced materials"

DOI: 10.1002/adma.202001808

Abstract: The recent success of immunotherapies has highlighted the power of leveraging the immune system in the fight against cancer. In order for most immune-based therapies to succeed, T cell subsets with the correct tumor-targeting specificities… read more here.

Keywords: cell membrane; antigen; engineered cell; cell ... See more keywords
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Engineered Cell Membrane Vesicles Expressing CD40 Alleviate System Lupus Nephritis by Intervening B Cell Activation

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Published in 2023 at "Small Methods"

DOI: 10.1002/smtd.202200925

Abstract: Immune intervention of B cell activation to blockade the production of autoantibodies provokes intense interest in the field of systemic lupus erythematosus (SLE) therapy development. Although the survival rate for SLE is improved, many patients… read more here.

Keywords: engineered cell; cell; cell membrane; cd40 nvs ... See more keywords
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Better by design: What to expect from novel CAR-engineered cell therapies?

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Published in 2022 at "Biotechnology advances"

DOI: 10.1016/j.biotechadv.2022.107917

Abstract: Chimeric antigen receptor (CAR) technology, and CAR-T cells in particular, have emerged as a new and powerful tool in cancer immunotherapy since demonstrating efficacy against several hematological malignancies. However, despite encouraging clinical results of CAR-T… read more here.

Keywords: cell therapies; car engineered; novel car; engineered cell ... See more keywords
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Efficient Whole-Cell Biotransformation for α-Arbutin Production through the Engineering of Sucrose Phosphorylase Combined with Engineered Cell Modification.

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Published in 2023 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.2c07972

Abstract: α-Arbutin is extensively used in cosmetic industries. The lack of highly active enzymes and the cytotoxicity of hydroquinone limit the biosynthesis of α-arbutin. In this study, a whole-cell biocatalytic approach based on enzyme engineering and… read more here.

Keywords: cell; engineered cell; cell modification; whole cell ... See more keywords
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Engineered cell-overexpression of circular RNA hybrid hydrogels promotes healing of calvarial defects.

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Published in 2022 at "Biomaterials science"

DOI: 10.1039/d2bm01472f

Abstract: Craniomaxillofacial bone defects seriously affect the physical and mental health of patients. Bone marrow mesenchymal stem cells (BMSCs) are "gold standard" cells used for bone repair. However, the collection of BMSCs is invasive, and the… read more here.

Keywords: engineered cell; circ cttn; overexpression circular; bone ... See more keywords
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TCR-engineered T cell therapy in solid tumors: State of the art and perspectives

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Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.adf3700

Abstract: T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell malignancies in hematology. However, their clinical impact on solid… read more here.

Keywords: engineered cell; cell; cell therapy; therapy solid ... See more keywords
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Time to evolve: predicting engineered T cell-associated toxicity with next-generation models

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Published in 2022 at "Journal for Immunotherapy of Cancer"

DOI: 10.1136/jitc-2021-003486

Abstract: Despite promising clinical results in a small subset of malignancies, therapies based on engineered chimeric antigen receptor and T-cell receptor T cells are associated with serious adverse events, including cytokine release syndrome and neurotoxicity. These… read more here.

Keywords: engineered cell; cell; evolve predicting; predicting engineered ... See more keywords
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Abstract 2584: Exosome molecular reference standards (Exo-Ref) generated from CRISPR/Cas9 engineered cell Lines for oncology diagnostic applications

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Published in 2019 at "Cancer Research"

DOI: 10.1158/1538-7445.sabcs18-2584

Abstract: Introduction: Exosomes (commonly known as extracellular vesicles) have generated tremendous interest for the therapeutic and diagnostic applications for oncology and other diseases. Specifically, exosome molecular cargo (proteins, nucleic acid, and small molecules) profiling have been… read more here.

Keywords: reference standards; exo ref; engineered cell; cell ... See more keywords
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Genetically engineered T-cell therapy for HPV-associated epithelial cancers: A first in human, phase I/II clinical trial.

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Published in 2018 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2018.36.15_suppl.3019

Abstract: 3019Background: Engineered T-cell therapy is an emerging treatment for hematological cancers. In epithelial cancers, its study has been limited. Human papillomavirus (HPV)-16+ epithelial cancers co... read more here.

Keywords: cell therapy; hpv; epithelial cancers; engineered cell ... See more keywords
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In vitro microglia models: the era of engineered cell microenvironments

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Published in 2023 at "Neural Regeneration Research"

DOI: 10.4103/1673-5374.363828

Abstract: Background: The most widely employed approach by cell biologists to performing in vitro cell culture assays is the one using 2D plastic culture ware systems, which allows reproducibility and ease of use. Moreover, this method… read more here.

Keywords: engineered cell; cell; models era; cell microenvironments ... See more keywords