Viral Vectors, Engineered Cells and the CRISPR Revolution.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-63904-8_1
Abstract: Over the past few decades the ability to edit human cells has revolutionized modern biology and medicine. With advances in genome editing methodologies, gene delivery and cell-based therapeutics targeted at treatment of genetic disease have… read more here.
Keywords: medicine; viral vectors; cells crispr; biology ... See more keywords
Genetically engineered T cells for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-019-0070-9
Abstract: T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy, by relying on this basic recognition method,… read more here.
Keywords: genetically engineered; engineered cells; cancer immunotherapy; cells cancer ... See more keywords
Plug-and-play fiber-optic sensors based on engineered cells for neurochemical monitoring at high specificity in freely moving animals.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.adg0218
Abstract: In vivo detection of neurochemicals, including neurotransmitters and neuromodulators, is critical for both understanding brain mechanisms and diagnosing brain diseases. However, few sensors are competent in monitoring neurochemical dynamics in vivo at high specificity. Here,… read more here.
Keywords: fiber optic; engineered cells; plug play; based engineered ... See more keywords
115 Engineered T cells directed at tumors with defined allelic loss
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0115
Abstract: Background Cell therapy, with all its promise as a powerful solid-tumor modality, is still hampered by the fundamental obstacle of cancer therapy: the acute shortage of truly tumor-specific targets. It is well known that an… read more here.
Keywords: tumor; signal integration; 115 engineered; cancer ... See more keywords
Identification of HLA-A0201 restricted epitope of novel cancer/testis antigens VCX/Y and generation of antigen-specific T-cell receptor engineered T cells for treatment of solid tumor malignancies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.5_suppl.160
Abstract: 160Background: To identify HLA-A0201 restricted epitope of novel cancer/testis antigen VCX/Y, generate antigen specific T cells and T-cell receptor (TCR) engineered T cells for adoptive cell therapy (ACT) of solid cancer patients. Methods: Reverse-immunology method… read more here.
Keywords: a0201 restricted; restricted epitope; hla a0201; a0201 ... See more keywords
Engineered cells along with smart scaffolds: critical factors for improving tissue engineering approaches.
Sign Up to like & getrecommendations! Published in 2022 at "Regenerative medicine"
DOI: 10.2217/rme-2022-0059
Abstract: In this review, gene delivery and its applications are discussed in tissue engineering (TE); also, new techniques such as the CRISPR-Cas9 system, synthetics biology and molecular dynamics simulation to improve the efficiency of the scaffolds have… read more here.
Keywords: tissue engineering; medicine; biology; engineered cells ... See more keywords
Engineered T cells and their therapeutic applications in autoimmune diseases
Sign Up to like & getrecommendations! Published in 2022 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2021.363
Abstract: Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting… read more here.
Keywords: therapeutic applications; cells therapeutic; car cells; autoimmune diseases ... See more keywords
Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1191278
Abstract: Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have received much attention for the improvement of obesity and metabolic disorders. However, even though the thermogenic and metabolic potential exists early after… read more here.
Keywords: engineered cells; metabolic benefits; adipose tissue; transplantation brown ... See more keywords
Engineered NK Cells Against Cancer and Their Potential Applications Beyond
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.825979
Abstract: Cell therapy is an innovative therapeutic concept where viable cells are implanted, infused, or grafted into a patient to treat impaired or malignant tissues. The term was first introduced circa the 19th century and has… read more here.
Keywords: cell; engineered cells; therapy; cells cancer ... See more keywords
Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.835762
Abstract: To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T). Unlike chimeric antigen receptors… read more here.
Keywords: cancer; engineered cells; tcr; cancer therapy ... See more keywords
Emerging Strategies in TCR-Engineered T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.850358
Abstract: Immunotherapy of cancer has made tremendous progress in recent years, as demonstrated by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient-derived tumor infiltrating lymphocytes, chimeric antigen receptor (CAR)-modified T cells (CAR-T)… read more here.
Keywords: tumor specific; engineered cells; emerging strategies; strategies tcr ... See more keywords