Abstract 2721: Sustained delivery of low-dose anti-CTLA-4 by genetically engineered encapsulated cells to the tumor microenvironment drives tumor response and prolongs survival in a colorectal cancer model
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DOI: 10.1158/1538-7445.am2023-2721
Abstract: Introduction: Systemic therapy with CTLA-4 blocking antibody (aCTLA-4) restores endogenous antitumor immunity and induces remarkable long-term clinical benefits in patients with melanoma. Yet immune-related side effects remain a major hurdle to extending its label to… read more here.
Keywords: engineered encapsulated; encapsulated cells; tumor; cancer ... See more keywords