High‐Performance Hydrogel‐Encapsulated Engineered Exosomes for Supporting Endoplasmic Reticulum Homeostasis and Boosting Diabetic Bone Regeneration
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202309491
Abstract: The regeneration of bone defects in diabetic patients still faces challenges, as the intrinsic healing process is impaired by hyperglycemia. Inspired by the discovery that the endoplasmic reticulum (ER) is in a state of excessive… read more here.
Keywords: homeostasis; endoplasmic reticulum; engineered exosomes; bone ... See more keywords
Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202504486
Abstract: Spinal cord injury (SCI) presents formidable therapeutic challenges due to its multifaceted pathological complexity. Here, this work reports engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 (G12G13MExos) that reprogram macrophages toward the M2c anti‐inflammatory phenotype and… read more here.
Keywords: spinal cord; hydrogel; delivery; engineered exosomes ... See more keywords
Engineered Exosomes Disguised NIR-II Nanoaggregates for High-Resolution Photoacoustic Angiography and Robust Photothermal Therapy of Glioblastoma.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c05448
Abstract: Glioblastoma (GBM) ranks as the most malignant tumor of the central nervous system. The blood-brain barrier (BBB) poses a formidable obstacle to drug delivery, while traditional invasive therapeutic modalities are plagued by substantial side effects… read more here.
Keywords: therapy; glioblastoma; nir nanoaggregates; resolution ... See more keywords
Engineered Exosomes Delivering bta-miR-223 Alleviate Staphylococcus aureus-Induced Mastitis in Mice via the TLR4/NF-κB Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c04371
Abstract: Bovine mastitis is an inflammatory disease of the mammary gland, frequently associated with infection by Staphylococcus aureus. Effective delivery of the antiinflammatory microRNA bta-miR-223 remains a challenge. In this study, we constructed engineered exosomes loaded… read more here.
Keywords: mir 223; engineered exosomes; staphylococcus aureus; bta mir ... See more keywords
A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications.
Sign Up to like & getrecommendations! Published in 2024 at "Biomaterials science"
DOI: 10.1039/d4bm00558a
Abstract: Exosomes exhibit high bioavailability, biological stability, targeted specificity, low toxicity, and low immunogenicity in shuttling various bioactive molecules such as proteins, lipids, RNA, and DNA. Natural exosomes, however, have limited production, targeting abilities, and therapeutic… read more here.
Keywords: comprehensive review; therapeutic applications; preparation; review engineered ... See more keywords
The research status and trends of engineered exosomes: a bibliometric analysis of the literature from web of science core collection.
Sign Up to like & getrecommendations! Published in 2025 at "Nanomedicine"
DOI: 10.1080/17435889.2025.2592969
Abstract: BACKGROUND In recent years, engineered exosomes have addressed the limitations of natural exosomes and gradually emerged as a new research hotspot. A comprehensive bibliometric analysis can reveal research trends and hotspots in this field, which… read more here.
Keywords: core; bibliometric analysis; engineered exosomes; research ... See more keywords
Genetically Engineered Exosomes as a Potential Regulator of Th1 Cells Response in Rheumatoid Arthritis.
Sign Up to like & getrecommendations! Published in 2023 at "Biopreservation and biobanking"
DOI: 10.1089/bio.2022.0003
Abstract: Background: Rheumatoid arthritis is a long-lasting inflammatory disease that usually involves joints, but it can also affect other organs, including the skin and lungs. In this case, it is important to maintain a balance between… read more here.
Keywords: derived exosomes; rheumatoid arthritis; mir 146a; engineered exosomes ... See more keywords
EXTH-38. ENGINEERED EXOSOMES FOR THERAPEUTIC GENE DELIVERY IN BRAIN TUMORS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.370
Abstract: The poor outcome of patients with glioblastoma (GBM) is at least partly due to the inability to deliver therapeutic agents to the tumor. We have shown that exosomes, naturally occurring nano-size extracellular vesicles, are capable… read more here.
Keywords: therapeutic gene; engineered exosomes; delivery; brain tumors ... See more keywords
Engineered Exosomes Loaded with miR-563 Inhibit Lung Cancer Growth
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/6141857
Abstract: The malignancy of lung cancer (LC) is serious in the world. Exosomes are well-known natural nanovesicles, which are reported to have the potential to carry functional miRNAs as natural carriers and deliver chemotherapeutic drugs. However,… read more here.
Keywords: engineered exosomes; lung cancer; tumor; mir 563 ... See more keywords
Abstract 1139: CD206 positive M2-macrophage targeting engineered exosomes as a potential diagnostic and therapeutic tool
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1139
Abstract: Tumor initiation and evolution is driven by the reciprocal actions between stromal and immune cells within the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) specifically M2-macrophages, a critical component of TME; participate in immune suppression, epithelial… read more here.
Keywords: 111in oxine; cd206 positive; positive macrophage; engineered exosomes ... See more keywords
Abstract CT265: KRASG12Dtargeting using engineered exosomes in pancreatic cancer: Results from the iEXPLORE phase 1 trial
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-ct265
Abstract: Despite its pivotal role in pancreatic ductal adenocarcinoma (PDAC), oncogenic Kras has eluded pharmacological targeting design, albeit with more recent and promising development. Given the preponderance of KrasG12D mutation in PDAC, we engineered exosomes from… read more here.
Keywords: cancer; using engineered; trial; engineered exosomes ... See more keywords