Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202102641
Abstract: Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as… read more here.
Keywords: extracellular matrices; matrices integrated; engineered extracellular; mechanobiology ... See more keywords
Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury.
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DOI: 10.1002/adma.202210579
Abstract: Acute respiratory distress syndrome (ARDS) represents a significant burden to the health care system, with approximately 200,000 cases diagnosed annually in the US. ARDS patients suffer from severe refractory hypoxemia, alveolar-capillary barrier dysfunction, impaired surfactant… read more here.
Keywords: dermal fibroblasts; inflammation; engineered extracellular; lung ... See more keywords
Transcript Engineered Extracellular Vesicles Alleviate Alloreactive Dynamics in Renal Transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202633
Abstract: Direct contact of membrane molecules and cytokine interactions orchestrate immune homeostasis. However, overcoming the threshold of distance and velocity barriers, and achieving adhesion mediated immune interaction remain difficult. Here, inspired by the natural chemotaxis of… read more here.
Keywords: extracellular vesicles; vesicles alleviate; engineered extracellular; foe tevs ... See more keywords
Engineered extracellular vesicles encapsulated Bryostatin-1 as therapy for neuroinflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr05517h
Abstract: Targeted and effective drug delivery to central nervous system (CNS) lesions is a major challenge in the treatment of multiple sclerosis (MS). Extracellular vesicles (EVs) have great promise as a drug delivery nanosystem given their… read more here.
Keywords: extracellular vesicles; encapsulated bryostatin; cns; engineered extracellular ... See more keywords
Advances of engineered extracellular vesicles-based therapeutics strategy
Sign Up to like & getrecommendations! Published in 2022 at "Science and Technology of Advanced Materials"
DOI: 10.1080/14686996.2022.2133342
Abstract: ABSTRACT Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer membrane-bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and lipids. They mediate intercellular communication through transporting internally packaged molecules, making them… read more here.
Keywords: extracellular vesicles; vesicles based; advances engineered; engineered extracellular ... See more keywords
Application of engineered extracellular vesicles to overcome drug resistance in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1070479
Abstract: Targeted therapies have significantly improved survival rates and quality of life for many cancer patients. However, on- and off-target side toxicities in normal tissues, and precocious activation of the immune response remain significant issues that… read more here.
Keywords: extracellular vesicles; engineered extracellular; application engineered; vesicles overcome ... See more keywords
Strong SARS-CoV-2 N-Specific CD8+ T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020329
Abstract: SARS-CoV-2-specific CD8+ T cell immunity is expected to counteract viral variants in both efficient and durable ways. We recently described a way to induce a potent SARS-CoV-2 CD8+ T immune response through the generation of… read more here.
Keywords: cov specific; engineered extracellular; specific cd8; mice ... See more keywords