Off-the-shelf tissue engineered heart valves for in situ regeneration: current state, challenges and future directions
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Medical Devices"
DOI: 10.1080/17434440.2018.1419865
Abstract: ABSTRACT Introduction: Transcatheter aortic valve replacement (TAVR) is continuously evolving and is expected to surpass surgical valve implantation in the near future. Combining durable valve substitutes with minimally invasive implantation techniques might increase the clinical… read more here.
Keywords: engineered heart; tissue; tissue engineered; valve ... See more keywords
Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abd1817
Abstract: A dynamic mechanical loading platform was developed to improve contractility of engineered heart tissues and study cardiac disease progression. Enhancing EHT platforms Although several engineered heart tissue (EHT) systems have been developed, most are not… read more here.
Keywords: dynamic loading; heart; engineered heart; disease ... See more keywords
Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266834
Abstract: The use of Engineered Heart Tissues (EHT) as in vitro model for disease modeling and drug screening has increased, as they provide important insight into the genetic mechanisms, cardiac toxicity or drug responses. Consequently, this… read more here.
Keywords: heart tissues; standalone application; engineered heart; analysis ... See more keywords
Human Engineered Heart Tissue Models for Disease Modeling and Drug Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.855763
Abstract: The emergence of human induced pluripotent stem cells (hiPSCs) and efficient differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased donors have the potential to recapitulate the molecular and functional features of the human heart. Although… read more here.
Keywords: engineered heart; drug; hipsc cms; human engineered ... See more keywords
Scaffold-Free Tubular Engineered Heart Tissue From Human Induced Pluripotent Stem Cells Using Bio-3D Printing Technology in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.806215
Abstract: Engineered heart tissues (EHTs) that are fabricated using human induced pluripotent stem cells (hiPSCs) have been considered as potential cardiac tissue substitutes in case of heart failure. In the present study, we have created hiPSC-derived… read more here.
Keywords: hipsc cos; induced pluripotent; heart; tissue ... See more keywords
A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12020214
Abstract: Cardiomyocytes derived from human pluripotent stem cells (hPSC-CMs) hold a great potential as human in vitro models for studying heart disease and for drug safety screening. Nevertheless, their associated immaturity relative to the adult myocardium… read more here.
Keywords: heart tissues; platform; new versatile; heart ... See more keywords