Overexpression of interleukin‐10 in engineered macrophages protects endothelial cells against LPS‐induced injury in vitro
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13365
Abstract: Endothelial dysfunction is a primary pathophysiological change in sepsis. Macrophages are known to interact with vascular endothelial cells during the development of sepsis. Recently, drug delivery based on engineered macrophages was reported as an alternative… read more here.
Keywords: engineered macrophages; endothelial cells; lps induced; cells lps ... See more keywords
Engineered Macrophages: A Safe-by-Design Approach for the Tumor Targeting Delivery of Sub-5 nm Gold Nanoparticles.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205474
Abstract: Ultrasmall nanoparticles (NPs) are a promising platform for the diagnosis and therapy of cancer, but the particles in sizes as small as several nanometers have an ability to translocate across biological barriers, which may bring… read more here.
Keywords: engineered macrophages; safe design; design approach; gold ... See more keywords
Thermally Controlled State Switches for Engineered Macrophages
Sign Up to like & getrecommendations! Published in 2025 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.5c00395
Abstract: Advances in cellular immunotherapy promise new treatments for conditions such as cancer, autoimmune disease, and heart disease. While engineered cells have the ability to recognize clinically relevant signals, traffic to disease sites and interface with… read more here.
Keywords: thermally controlled; biology; switches engineered; controlled state ... See more keywords
Abstract P2-02-15: Engineered macrophages secreting TRAIL achieve immunotherapy for triple-negative breast cancer by inhibiting the Wnt/β-catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p2-02-15
Abstract: Macrophages play a critical role in the body's defense against cancer by phagocytosing tumor cells, presenting antigens, and activating adaptive T cells. However, macrophages are intrinsically incapable of delivering targeted cancer immunotherapies. Engineered adoptive cell… read more here.
Keywords: breast cancer; engineered macrophages; triple negative; trail ... See more keywords