Got Milk? Identifying and Characterizing Lactation Defects in Genetically-Engineered Mouse Models
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-020-09467-y
Abstract: The ability to produce and expel milk is important for the health and survival of all mammals. Nevertheless, our understanding of the molecular events underlying the execution of this process remains incomplete. Whilst impaired mammary… read more here.
Keywords: genetically engineered; mouse models; biology; lactation defects ... See more keywords
Antitumoral effects of attenuated Listeria monocytogenes in a genetically engineered mouse model of melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0681-1
Abstract: Attenuated Listeria monocytogenes (Lmat-LLO) represents a valuable anticancer vaccine and drug delivery platform. Here we show that in vitro Lmat-LLO causes ROS production and, in turn, apoptotic killing of a wide variety of melanoma cells,… read more here.
Keywords: genetically engineered; melanoma; attenuated listeria; lmat llo ... See more keywords
Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1708391114
Abstract: Significance RAS mutant cancers represent a large unmet clinical need. Kras mutant genetically engineered mouse models (GEMMs) of cancer recapitulate disease characteristics and are relied upon preclinically to validate targets and test therapies. Our integrative… read more here.
Keywords: genetically engineered; mouse models; kras mutant; cancer ... See more keywords
Preprint Highlight: Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-03-1008
Abstract: Developing cancer immunotherapies relies on an accurate understanding of the diversity of cancer antigen–MHC complexes presented by immune cells, yet popular in vitro cell culture systems do not fully replicate the native tumor microenvironment. To… read more here.
Keywords: cell; vivo; engineered mouse; tumor ... See more keywords
Abstract B37: Understanding DCIS initiation and progression using PDX and genetically engineered mouse and rat models
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-b37
Abstract: Ductal carcinoma in situ (DCIS) is a starting lesion in the milk duct of the breast, which accounts for 25% of all “breast cancers” detected. DCIS is usually treated by surgery combined with radiotherapy, which… read more here.
Keywords: genetically engineered; engineered mouse; dcis; progression ... See more keywords
An update on genetically engineered mouse models of pancreatic neuroendocrine neoplasms.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0166
Abstract: Pancreatic neuroendocrine neoplasms (PanNENs) are rare and clinically challenging entities. At the molecular level, PanNENs' genetic profile is well-characterized but there is limited knowledge regarding the contribution of the newly identified genes to tumor initiation… read more here.
Keywords: gemms; neuroendocrine neoplasms; engineered mouse; pancreatic neuroendocrine ... See more keywords
Genetically Engineered Mouse Models of Gliomas: Technological Developments for Translational Discoveries
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11091335
Abstract: The most common brain tumours, gliomas, have significant morbidity. Detailed biological and genetic understanding of these tumours is needed in order to devise effective, rational therapies. In an era generating unprecedented quantities of genomic sequencing… read more here.
Keywords: genetically engineered; models gliomas; mouse models; gliomas technological ... See more keywords