Hypoxia transactivates cholecystokinin gene expression in 3D-engineered muscle.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2021.03.006
Abstract: At high altitudes, the hypoxic atmosphere decreases the oxygen partial pressure in the body, inducing several metabolic changes in tissues and cells. Furthermore, it exerts potent anorectic effects, thus causing an energy deficit. Two decades… read more here.
Keywords: expression engineered; muscle; engineered muscle; cck ... See more keywords
Macrophages rescue injured engineered muscle
Sign Up to like & getrecommendations! Published in 2018 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-018-0312-0
Abstract: Engineered skeletal muscle self-repairs when incorporating bone-marrow-derived macrophages, which prevent the apoptosis of resident muscle stem cells. read more here.
Keywords: injured engineered; muscle; macrophages rescue; rescue injured ... See more keywords
Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1056-4
Abstract: Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle beyond the inherent regenerative capacity of the body, generally leading to severe functional deficit. Formation of appropriate somato-motor innervations remains one of… read more here.
Keywords: muscle; volumetric muscle; engineered muscle; tissue engineered ... See more keywords
Mechanical unloading in 3D-engineered muscle leads to muscle atrophy by suppressing protein synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00323.2021
Abstract: Three dimensional (3D)-engineered muscle is an useful approach to a more comprehensive understanding of molecular mechanisms underlying unloading-induced muscle atrophy. We investigated the effects of mechanical unloading on molecular muscle protein synthesis (MPS)- and muscle… read more here.
Keywords: muscle; muscle atrophy; mechanical unloading; engineered muscle ... See more keywords
Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.937899
Abstract: Exercise affects the expression of microRNAs (miR/s) and muscle-derived extracellular vesicles (EVs). To evaluate sarcoplasmic and secreted miR expression in human skeletal muscle in response to exercise-mimetic contractile activity, we utilized a three-dimensional tissue-engineered model… read more here.
Keywords: extracellular vesicles; muscle; expression; tissue engineered ... See more keywords
Contractile force assessment methods for in vitro skeletal muscle tissues
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.77204
Abstract: Over the last few years, there has been growing interest in measuring the contractile force (CF) of engineered muscle tissues to evaluate their functionality. However, there are still no standards available for selecting the most… read more here.
Keywords: contractile force; engineered muscle; muscle; muscle tissues ... See more keywords