Biosensing in Smart Engineered Probiotics
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Journal"
DOI: 10.1002/biot.201900319
Abstract: Engineered microbes are exciting alternatives to current diagnostics and therapeutics. Researchers have developed a wide range of genetic tools and parts to engineer probiotic and commensal microbes. Among these tools and parts, biosensors allow the… read more here.
Keywords: biosensing smart; engineered probiotics; smart engineered;
Engineered Probiotics-Based Biohybrid-Driven Tumor Metabolic Remodeling To Boost Tumor Photoimmunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.5c02850
Abstract: Bioengineered probiotics enable new opportunities to address abnormal cancer metabolism and suppressive immune-environment interactions for improved therapeutic susceptibility. Here, Escherichia coli Nissle 1917 (EcN) was constructed to convert ammonia into l-arginine continuously and was further… read more here.
Keywords: engineered probiotics; tumor metabolic; probiotics based; tumor ... See more keywords
Engineered Probiotics Remodel the Tumor Immune Microenvironment.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.5c13557
Abstract: Living treatments signify novel anticancer strategies employing living microorganisms with selective tropism to achieve effective therapeutic results. Nevertheless, the effective translation of bacterial biological products into clinical applications is still challenging, mainly because primitive microorganisms… read more here.
Keywords: probiotics remodel; engineered probiotics; tumor immune; remodel tumor ... See more keywords
Intestinal Engineered Probiotics as Living Therapeutics: Chassis Selection, Colonization Enhancement, Gene Circuit Design, and Biocontainment.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00314
Abstract: Intestinal probiotics are often used for the in situ treatment of diseases, such as metabolic disorders, tumors, and chronic inflammatory infections. Recently, there has been an increased emphasis on intelligent, customized treatments with a focus… read more here.
Keywords: intestinal engineered; engineered probiotics; colonization; design ... See more keywords
Engineered probiotics as live biotherapeutics for diagnosis and treatment of human diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in microbiology"
DOI: 10.1080/1040841x.2023.2190392
Abstract: The use of probiotics to regulate the intestinal microbiota to prevent and treat a large number of disorders and diseases has been an international research hotspot. Although conventional probiotics have a certain regulatory role in… read more here.
Keywords: engineered probiotics; probiotics live; diagnosis treatment; live biotherapeutics ... See more keywords
Engineered Probiotics: Applications and Biological Containment.
Sign Up to like & getrecommendations! Published in 2017 at "Annual review of food science and technology"
DOI: 10.1146/annurev-food-030216-030256
Abstract: Bioengineered probiotics represent the next generation of whole cell-mediated biotherapeutics. Advances in synthetic biology, genome engineering, and DNA sequencing and synthesis have enabled scientists to design and develop probiotics with increased stress tolerance and the… read more here.
Keywords: probiotics applications; engineered probiotics; applications biological; biology ... See more keywords
A Review of the Use of Native and Engineered Probiotics for Colorectal Cancer Therapy
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25073896
Abstract: Colorectal cancer (CRC) is a serious global health concern, and researchers have been investigating different strategies to prevent, treat, or support conventional therapies for CRC. This review article comprehensively covers CRC therapy involving wild-type bacteria,… read more here.
Keywords: colorectal cancer; cancer; engineered probiotics; therapy ... See more keywords