Modular Antigen‐Specific T‐cell Biofactories for Calibrated In Vivo Synthesis of Engineered Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201800210
Abstract: An artificial cell‐signaling pathway is developed that capitalizes on the T‐cell's innate extravasation ability and transforms it into a vector (T‐cell Biofactory) for synthesizing calibrated amounts of engineered proteins in vivo. The modularity of this… read more here.
Keywords: cell biofactory; specific cell; antigen specific; cell ... See more keywords
Bioinspired Functionally Graded Composite Assembled Using Cellulose Nanocrystals and Genetically Engineered Proteins with Controlled Biomineralization.
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DOI: 10.1002/adma.202102658
Abstract: Nature provides unique insights into design strategies evolved by living organisms to construct robust materials with a combination of mechanical properties that are challenging to replicate synthetically. Hereby, inspired by the impact-resistant dactyl club of… read more here.
Keywords: genetically engineered; functionally graded; bioinspired functionally; graded composite ... See more keywords
Inverse pharmacology: Approaches and tools for introducing druggability into engineered proteins
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Advances"
DOI: 10.1016/j.biotechadv.2019.107439
Abstract: A major feature of twenty-first century medical research is the development of therapeutic strategies that use ‘biologics’ (large molecules, usually engineered proteins) and living cells instead of, or as well as, the small molecules that… read more here.
Keywords: small molecules; pharmacology; pharmacology approaches; inverse pharmacology ... See more keywords
Genetically Engineered Proteins to Improve Biomass Conversion: New Advances and Challenges for Tailoring Biocatalysts
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24162879
Abstract: Protein engineering emerged as a powerful approach to generate more robust and efficient biocatalysts for bio-based economy applications, an alternative to ecologically toxic chemistries that rely on petroleum. On the quest for environmentally friendly technologies,… read more here.
Keywords: genetically engineered; improve biomass; proteins improve; biomass ... See more keywords