Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution
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DOI: 10.1038/s41467-024-46239-2
Abstract: The Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or GPR109A, is a prototypical GPCR that plays a central role in the inhibition of lipolytic and atherogenic activities. Its activation also results… read more here.
Keywords: receptor; guided engineering; engineering biased; structure guided ... See more keywords