Abstract IA08: Engineering T cells to resist and convert immunosuppressive tumor microenvironments
Sign Up to like & getrecommendations! Published in 2018 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm17-ia08
Abstract: A major challenge in adoptive T-cell therapy for solid tumors is the harsh immunosuppressive tumor microenvironment. Soluble factors such as transforming growth factor beta (TGF-β) play key roles in tumor immune evasion. Here, we report… read more here.
Keywords: resist convert; immunosuppressive tumor; cells resist; engineering cells ... See more keywords
Engineering γδ T Cells: Recognizing and Activating on Their Own Way
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DOI: 10.3389/fimmu.2022.889051
Abstract: Adoptive cell therapy (ACT) with engineered T cells has emerged as a promising strategy for the treatment of malignant tumors. Among them, there is great interest in engineered γδ T cells for ACT. With both… read more here.
Keywords: engineered cells; engineering cells; cells recognizing; recognizing activating ... See more keywords
Migratory Engineering of T Cells for Cancer Therapy
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DOI: 10.3390/vaccines10111845
Abstract: Adoptive cell therapy (ACT) and chimeric antigen receptor (CAR) T cell therapy in particular represents an adaptive, yet versatile strategy for cancer treatment. Convincing results in the treatment of hematological malignancies have led to FDA… read more here.
Keywords: cell; engineering cells; therapy; solid tumors ... See more keywords