Engineering and evaluation of FXa bypassing agents that restore hemostasis following Apixaban associated bleeding
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48278-1
Abstract: Direct oral anticoagulants (DOACs) targeting activated factor Xa (FXa) are used to prevent or treat thromboembolic disorders. DOACs reversibly bind to FXa and inhibit its enzymatic activity. However, DOAC treatment carries the risk of anticoagulant-associated… read more here.
Keywords: engineering evaluation; associated bleeding; fxa; evaluation fxa ... See more keywords
Engineering and evaluation of amyloid assemblies as a nanovaccine against the Chikungunya virus.
Sign Up to like & getrecommendations! Published in 2018 at "Nanoscale"
DOI: 10.1039/c8nr05948a
Abstract: The design of nanoparticles exposing a high density of antigens constitutes a promising strategy to address safety concerns of conventional life-attenuated vaccines as well as to increase the immunogenicity of subunit vaccines. In this study,… read more here.
Keywords: chikungunya virus; engineering evaluation; amyloid assemblies; microscopy ... See more keywords