Flavonoids, terpenoids, and polyketide antibiotics: Role of glycosylation and biocatalytic tactics in engineering glycosylation.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2020.107550
Abstract: Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as glycosides, in which sugar residues act as a decisive factor in their… read more here.
Keywords: polyketide antibiotics; terpenoids polyketide; engineering glycosylation; glycosylation ... See more keywords
Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1003065
Abstract: Molecular pharming in plants offers exciting possibilities to address global access to modern biologics. However, differences in the N-glycosylation pathway including the presence of β(1,2)-xylose and core α(1,3)-fucose can affect activity, potency and immunogenicity of… read more here.
Keywords: tabacum; glycosylation pathway; molecular pharming; using crispr ... See more keywords