Engineering Macrophages for Cancer Immunotherapy and Drug Delivery.
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DOI: 10.1002/adma.202002054
Abstract: Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can phagocytose tumor cells, while anti-inflammatory M2 macrophages such as tumor-associated macrophages (TAMs) promote tumor growth and invasion. Modulating the tumor immune… read more here.
Keywords: drug delivery; drug; engineering macrophages; cancer ... See more keywords
X‐ray‐Guided In Situ Genetic Engineering of Macrophages for Sustained Cancer Immunotherapy
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DOI: 10.1002/adma.202208059
Abstract: Effective repolarization of macrophages has emerged as a promising approach for anticancer therapy. However, there are very few studies on the effect of reprogramming macrophages from M2 phenotype to M1 phenotype without reconversion while maintaining… read more here.
Keywords: genetic engineering; engineering macrophages; ray guided; situ genetic ... See more keywords
Engineering macrophages to eat cancer: from “marker of self” CD47 and phagocytosis to differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.4ri1216-516r
Abstract: The ability of a macrophage to engulf and break down invading cells and other targets provides a first line of immune defense in nearly all tissues. This defining ability to “phagos” or devour can subsequently… read more here.
Keywords: phagocytosis; differentiation; engineering macrophages; eat cancer ... See more keywords