Rational engineering of minimally immunogenic nucleases for gene therapy
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DOI: 10.1038/s41467-024-55522-1
Abstract: Genome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases. However, cellular and humoral immunogenicity of genome editing tools, which originate from bacteria, complicates their clinical use. Here we report… read more here.
Keywords: engineering minimally; genome editing; engineering; rational engineering ... See more keywords