Engineering a Protein Binder Specific for p38α with Interface Expansion.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00408
Abstract: Protein binding specificities can be manipulated by redesigning contacts that already exist at an interface or by expanding the interface to allow interactions with residues adjacent to the original binding site. Previously, we developed a… read more here.
Keywords: protein; engineering protein; monobody; protein binder ... See more keywords
Engineering Protein-Nanoparticle Hybrids as Targeted Contrast Agents.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c12799
Abstract: Iron oxide nanoparticles (IONPs) have shown great promise in biomedical applications, particularly as MRI contrast agents due to their magnetic properties and biocompatibility. Although several IONPs have been approved by regulatory agencies as MRI contrast… read more here.
Keywords: protein nanoparticle; engineering protein; contrast agents; contrast ... See more keywords
Engineering protein assemblies with allosteric control via monomer fold-switching.
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.2210/pdb6qiz/pdb
Abstract: The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite enormous interest, the design of nanoscale allosteric assemblies has proven tremendously challenging. Here we present a… read more here.
Keywords: engineering protein; monomer; protein assemblies; allosteric control ... See more keywords