Engineering pH-Responsive Dendrimer-STAT3 Inhibitor Conjugates for Intracellular Delivery.
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DOI: 10.1021/acs.biomac.5c01648
Abstract: Small-molecule STAT3 inhibitors face numerous challenges in clinical translation, including poor water solubility, rapid systemic clearance, low bioavailability, poor selectivity, and high cytotoxicity. To address these limitations, we conjugated the potent STAT3 inhibitor-LLL12 to generate… read more here.
Keywords: dendrimer; engineering responsive; delivery; stat3 inhibitor ... See more keywords