Protein Engineering Strategies for Improved Pharmacokinetics
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202101633
Abstract: Protein therapeutics have gained momentum in recent years and become a pillar in treating many diseases and the only choice in several ailments. Protein therapeutics are highly specific, tunable, and less toxic than conventional small… read more here.
Keywords: engineering strategies; engineering; half life; strategies improved ... See more keywords
A cocktail of protein engineering strategies: Breaking the enzyme bottleneck one by one for high UTP production in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28061
Abstract: The pyrimidine metabolic pathway is tightly regulated in microorganisms, allowing limited success in metabolic engineering for the production of pathway‐related substances. Here, we constructed a four‐enzyme coupled system for the in vitro production of uridine… read more here.
Keywords: engineering strategies; kinase; protein engineering; production ... See more keywords
Recent advances, challenges and metabolic engineering strategies in the biosynthesis of 3‐hydroxypropionic acid
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28170
Abstract: As an attractive and valuable platform chemical, 3‐hydroxypropionic acid (3‐HP) can be used to produce a variety of industrially important commodity chemicals and biodegradable polymers. Moreover, the biosynthesis of 3‐HP has drawn much attention in… read more here.
Keywords: hydroxypropionic acid; metabolic engineering; engineering strategies; advances challenges ... See more keywords
Engineering strategies to capture the biological and biophysical tumor microenvironment in vitro.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.113852
Abstract: Despite decades of research and advancements in diagnostic and treatment modalities, cancer remains a major global healthcare challenge. This is due in part to a lack of model systems that allow investigating the mechanisms underlying… read more here.
Keywords: strategies capture; engineering strategies; biological biophysical; cell ... See more keywords
Extremophilic exopolysaccharides: A review and new perspectives on engineering strategies and applications.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.10.011
Abstract: Numerous microorganisms inhabiting harsh niches produce exopolysaccharides as a significant strategy to survive in extreme conditions. The exopolysaccharides synthesized by extremophiles possess distinctive characteristics due to the varied harsh environments which stimulate the microorganisms to… read more here.
Keywords: review new; applications extremophilic; engineering strategies; exopolysaccharides review ... See more keywords
Metabolic engineering strategies toward production of biofuels.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2020.02.009
Abstract: Exacerbation of climate change and air pollution around the world have emphasized the necessity of replacing fossil fuels with clean and sustainable energy. Metabolic engineering has provided strategies to engineer diverse organisms for the production… read more here.
Keywords: engineering; production; metabolic engineering; engineering strategies ... See more keywords
Recent insights in microbial exopolysaccharide biosynthesis and engineering strategies.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2018.01.005
Abstract: The distinct biosynthesis pathways for microbial exopolysaccharide production provide different engineering strategies to tailor the chemical structures of the final polymers. This review focuses on the latest insights in the various pathways and identifies bottlenecks… read more here.
Keywords: engineering; biosynthesis; production; engineering strategies ... See more keywords
Eco-engineering strategies for soil restoration and water conservation: Investigating the application of soil improvements in a semi-arid climate in a medical facility case study, Abu Dhabi
Sign Up to like & getrecommendations! Published in 2017 at "Ecological Engineering"
DOI: 10.1016/j.ecoleng.2017.07.020
Abstract: This article was published in Ecological Engineering, Corrected proof online on 21 July 2017 available at https://doi.org/10.1016/j.ecoleng.2017.07.020 read more here.
Keywords: soil restoration; engineering; restoration water; engineering strategies ... See more keywords
Metabolic engineering strategies for caffeic acid production in Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "Electronic Journal of Biotechnology"
DOI: 10.1016/j.ejbt.2018.12.004
Abstract: Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is an aromatic compound obtained by the phenylpropanoid pathway. This natural product has antioxidant, antitumor, antiviral, and anti-inflammatory activities. It is also a precursor of CA phenethyl ester (CAPE), a… read more here.
Keywords: engineering strategies; production; escherichia coli; metabolic engineering ... See more keywords
Engineering Strategies for Allogeneic Solid Tissue Acceptance.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2021.03.005
Abstract: Advances in allogeneic transplantation of solid organs and tissues depend on our understanding of mechanisms that mediate the prevention of graft rejection. For the past decades, clinical practice has established guidelines to prevent allograft rejection,… read more here.
Keywords: solid tissue; strategies allogeneic; rejection; engineering strategies ... See more keywords
Molecular engineering strategies and methods for the expression and purification of IgG1-based bispecific bivalent antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2018.08.004
Abstract: In recent years, bispecific antibodies (BisAbs) have emerged as novel pharmaceutical candidates owing to their ability to engage two disease mediators simultaneously, thus providing a possible alternative therapeutic approach in complex diseases such as cancer… read more here.
Keywords: strategies methods; engineering strategies; expression; molecular engineering ... See more keywords