Engineering Streptomyces albus B4 for Enhanced Production of (R)-Mellein: A High-Titer Heterologous Biosynthesis Approach.
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DOI: 10.1021/acs.jafc.4c02463
Abstract: The natural compound (R)-(-)-mellein exhibits antiseptic and fungicidal activities. We investigated its biosynthesis using the polyketide synthase encoded by SACE_5532 (pks8) from Saccharopolyspora erythraea heterologously expressed in Streptomyces albus B4, a chassis chosen for its… read more here.
Keywords: high titer; biosynthesis; engineering streptomyces; streptomyces albus ... See more keywords