Enhanced antitumor efficacy of glutathione-responsive chitosan based nanoparticles through co-delivery of chemotherapeutics, genes, and immune agents.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.118384
Abstract: To achieve the co-delivery of chemotherapeutic drugs, genes, and immune agents in a single nanoparticulate system, p-mercaptobenzoic acid-grafted N, N, N-trimethyl chitosan nanoparticles (MT NPs) were successfully synthesized. Paclitaxel (PTX) was encapsulated into the hydrophobic… read more here.
Keywords: immune agents; delivery; enhanced antitumor; chitosan based ... See more keywords
Structural Optimization of Pyrazole Compounds as Hsp90 Regulators with Enhanced Antitumor Activity.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02182
Abstract: Targeting Hsp90 is an effective strategy for cancer therapy. TAS-116 has been approved for the treatment of gastrointestinal stromal tumors. Our previous studies identified a series of pyrazole derivatives as covalent Hsp90 inhibitors that allosterically… read more here.
Keywords: enhanced antitumor; antitumor activity; structural optimization; pyrazole ... See more keywords
Enhanced Antitumor Efficacy and Reduced Myelosuppression by a Supramolecular Complex Composed of Azocalix[4]arene and Sunitinib.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c02487
Abstract: Antiangiogenic therapy, which inhibits tumor growth by blocking oxygen and nutrition supply, represents a promising strategy for antineoplastic therapy. However, the widespread biodistribution of antiangiogenic agents often leads to off-target toxicities, including hematotoxicity and myelosuppression.… read more here.
Keywords: myelosuppression; azocalix arene; efficacy; enhanced antitumor ... See more keywords
Enhanced Antitumor Immune Responses via a Self-Assembled Carrier-Free Nanovaccine.
Sign Up to like & getrecommendations! Published in 2021 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c00648
Abstract: Nanovaccines have emerged as promising agents for cancer immunotherapy. However, insufficient antitumor immunity caused by inefficient antigen/adjuvant loading and complicated preparation processes are the major obstacles that limit their clinical application. Herein, two adjuvants, monophosphatidyl… read more here.
Keywords: immune responses; enhanced antitumor; via self; responses via ... See more keywords
EXTH-58. BLOCKING IMMUNE CHECKPOINT— LAIR1: DISRUPTING THE LAIR1—FXIII-A—COLLAGEN IMMUNOSUPPRESSIVE CIRCUIT FOR ENHANCED ANTITUMOR THERAPEUTICS
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0989
Abstract: Recent evidence indicates that tumor-associated myeloid cells (TAMCs), including tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), play a crucial role in glioblastoma (GBM) immunosuppression and progression. These cells can constitute up to 50% of… read more here.
Keywords: immune checkpoint; enhanced antitumor; tumor; lair1 ... See more keywords
“Shell-Core” Bilayer Nanoparticle as Chemotherapeutic Drug Co-Delivery Platforms Render Synchronized Microenvironment Respond and Enhanced Antitumor Effects
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s401038
Abstract: Background Synergistic chemotherapy has been proved as an effective antitumor means in clinical practice. However, most co-administration treatment often lacks simultaneous control over the release of different chemotherapeutic agents. Materials and Methods β-cyclodextrin modified hyaluronic… read more here.
Keywords: shell core; enhanced antitumor; core bilayer; release ... See more keywords
Progress and prospects of nanozymes for enhanced antitumor therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1090795
Abstract: Nanozymes are nanomaterials with mimicked enzymatic activity, whose catalytic activity can be designed by changing their physical parameters and chemical composition. With the development of biomedical and material science, artificially created nanozymes have high biocompatibility… read more here.
Keywords: progress prospects; nanozymes enhanced; enhanced antitumor; therapy ... See more keywords
Novel Camptothecin Derivative 9c with Enhanced Antitumor Activity via NSA2-EGFR-P53 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26051987
Abstract: Therapeutic challenges persist in the management of non-small cell lung cancer (NSCLC) in oncology. Camptothecins have demonstrated as crucial agents in tumor therapy; however, their efficacy is significantly hindered by adverse effects and drug resistance.… read more here.
Keywords: camptothecin derivative; p53; nsa2 egfr; enhanced antitumor ... See more keywords
[Corrigendum] Enhanced antitumor activity by the combination of dasatinib and combretastatin A‑4 in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2024 at "Oncology Reports"
DOI: 10.3892/or.2024.8783
Abstract: Following the publication of this article, an interested reader drew to the authors' attention that the flow cytometric (FCM) plots in Fig. 2A on p. 2278 showing the 'Dasatinib' and 'CA‑4' experiments were duplicates of… read more here.
Keywords: oncology; corrigendum enhanced; corrigendum; enhanced antitumor ... See more keywords