Rationally Designed Amanitins Achieve Enhanced Cytotoxicity.
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DOI: 10.1021/acs.jmedchem.1c02226
Abstract: For 70 years, α-amanitin, the most cytotoxic peptide in its class, has been without a synthetic rival; through synthesis, we address the structure-activity relationships to inform the design of new amatoxins and disclose analogues that… read more here.
Keywords: rationally designed; cytotoxicity; designed amanitins; enhanced cytotoxicity ... See more keywords