Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factor of vaccine-enhanced disease
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DOI: 10.1038/s41541-020-0181-x
Abstract: Vaccine-enhanced disease (VED) occurs as a result of vaccination followed by infection with virulent Mycoplasma pneumoniae. To date VED has prevented development of an efficacious vaccine against this significant human respiratory pathogen. Herein we report… read more here.
Keywords: vaccine enhanced; lipid moieties; enhanced disease; mycoplasma pneumoniae ... See more keywords
Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1
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DOI: 10.1093/plphys/kiac480
Abstract: Abstract Toll/Interleukin-1 receptor (TIR) domains are integral to immune systems across all kingdoms. In plants, TIRs are present in nucleotide-binding leucine-rich repeat (NLR) immune receptors, NLR-like, and TIR-only proteins. Although TIR-NLR and TIR signaling in… read more here.
Keywords: tir; toll interleukin; enhanced disease; disease susceptibility ... See more keywords
Vaccine-Associated Enhanced Disease and Pathogenic Human Coronaviruses
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DOI: 10.3389/fimmu.2022.882972
Abstract: Vaccine-associated enhanced disease (VAED) is a difficult phenomenon to define and can be confused with vaccine failure. Using studies on respiratory syncytial virus (RSV) vaccination and dengue virus infection, we highlight known and theoretical mechanisms… read more here.
Keywords: associated enhanced; pathogenic human; vaccine associated; pathology ... See more keywords
Severe Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced Disease
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DOI: 10.3389/fmed.2021.637642
Abstract: Infection by the novel SARS-CoV-2 coronavirus produces a range of outcomes, with the majority of cases producing mild or asymptomatic effects, and a smaller subset progressing to critical or fatal COVID-19 disease featuring severe acute… read more here.
Keywords: mechanisms immune; infection; disease; enhanced disease ... See more keywords
Vaccine-associated enhanced disease in humans and animal models: Lessons and challenges for vaccine development
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.932408
Abstract: The fight against infectious diseases calls for the development of safe and effective vaccines that generate long-lasting protective immunity. In a few situations, vaccine-mediated immune responses may have led to exacerbated pathology upon subsequent infection… read more here.
Keywords: associated enhanced; animal models; development; vaccine associated ... See more keywords