DNA corona on nanoparticles leads to an enhanced immunostimulatory effect with implications for autoimmune diseases
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2319634121
Abstract: Significance A mechanistic understanding of many autoimmune and inflammatory diseases is currently lacking. Recent work has shown that cell-free DNA bound to biological microparticles is linked to systemic lupus erythematosus and related conditions. However, the… read more here.
Keywords: immunostimulatory effect; dna corona; nanoparticles leads; corona nanoparticles ... See more keywords
Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0599-8
Abstract: BackgroundONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and immunomodulatory properties in preclinical models. The first-in-human trial of ONC201 previously established a… read more here.
Keywords: advanced solid; onc201; enhanced immunostimulatory; solid tumor ... See more keywords