Articles with "enhanced permeability" as a keyword



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Rapid and continuous accumulation of nitric oxide-releasing liposomes in tumors to augment the enhanced permeability and retention (EPR) effect.

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Published in 2019 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2019.05.043

Abstract: The modulation of blood flow to tumors is a prominent strategy for improving the tumor accumulation of nanomedicines, resulting from the enhanced permeability and retention (EPR) effect. We previously reported a promising EPR enhancer-a nitric… read more here.

Keywords: accumulation; permeability retention; epr effect; enhanced permeability ... See more keywords
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Parameters Affecting the Enhanced Permeability and Retention Effect: The Need for Patient Selection.

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Published in 2017 at "Journal of pharmaceutical sciences"

DOI: 10.1016/j.xphs.2017.06.019

Abstract: The enhanced permeability and retention (EPR) effect constitutes the rationale by which nanotechnologies selectively target drugs to tumors. Despite promising preclinical and clinical results, these technologies have, in our view, underachieved compared to their potential,… read more here.

Keywords: permeability retention; enhanced permeability; effect; epr effect ... See more keywords
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Enhanced permeability dielectric FeCo/Al2O3multilayer thin films with tailored properties deposited by magnetron sputtering on silicon

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Published in 2019 at "AIP Advances"

DOI: 10.1063/1.5079477

Abstract: We have studied the structural and magnetic properties of enhanced-permeability-dielectric FeCo/Al2O3-multilayer thin films deposited on 8"-Si wafers in an industrial magnetron sputtering system. The EPD-multilayers consist of 25 periods of alternating nanometer-thick FeCo-layers deposited by… read more here.

Keywords: feco layers; thin films; feco; al2o3 ... See more keywords
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Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide–Generating Agents Improves the Therapeutic Effects of Nanomedicines

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Published in 2018 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.mct-18-0696

Abstract: Enhanced permeability and retention (EPR) effect–based nanomedicine is a promising strategy for successful anticancer therapy. The EPR effect is based on tumor blood flow. Because advanced large tumors, as frequently seen in clinical settings, are… read more here.

Keywords: permeability retention; enhanced permeability; effect; epr effect ... See more keywords
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Enhanced Permeability and Retention Effect as a Ubiquitous and Epoch-Making Phenomenon for the Selective Drug Targeting of Solid Tumors

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Published in 2022 at "Journal of Personalized Medicine"

DOI: 10.3390/jpm12121964

Abstract: In 1979, development of the first polymer drug SMANCS [styrene-co-maleic acid (SMA) copolymer conjugated to neocarzinostatin (NCS)] by Maeda and colleagues was a breakthrough in the cancer field. When SMANCS was administered to mice, drug… read more here.

Keywords: epr effect; permeability retention; effect; retention effect ... See more keywords
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Approaches to Improve Macromolecule and Nanoparticle Accumulation in the Tumor Microenvironment by the Enhanced Permeability and Retention Effect

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Published in 2022 at "Polymers"

DOI: 10.3390/polym14132601

Abstract: Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing macromolecules deliver their payload selectively to solid tumors. An important driver of passive targeting is the enhanced permeability and retention (EPR) effect, which is… read more here.

Keywords: enhanced permeability; permeability retention; tumor; effect ... See more keywords