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Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120363
Abstract: Docetaxel (DTX) is a chemotherapeutic drug with poor hydrophilicity and permeability. Its lipophilic properties decrease its absorption in systemic circulation which hinders its therapeutic efficacy & safety. Cyclodextrins (CDs) with their unique structural properties enhance…
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Keywords:
polymeric nanoparticles;
enhanced solubility;
toxicity;
drug ... See more keywords
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Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.12.021
Abstract: Abstract Alamethicin (ALM) inhibits the growth of bacteria by disrupting their cell membrane. ALM exhibits poor solubility in aqueous medium thus limiting its application. A method is proposed for encapsulation of ALM with γ-cyclodextrin (γ-CD)…
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Keywords:
molar ratio;
enhanced solubility;
cyclodextrin;
alm molar ... See more keywords
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Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1775633
Abstract: Abstract Meloxicam (MLX) is a non-steroidal anti-inflammatory which is practically insoluble in water, requiring high concentrations to reach therapeutic levels and causing frequently gastrointestinal effects. In this way, the aim of this study was to…
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Keywords:
mlx;
saccharin;
enhanced solubility;
mandelic acid ... See more keywords
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Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s181175
Abstract: Background The present study aimed to develop orlistat-loaded solid self-nanoemulsifying drug delivery system preconcentrate (SSP) with the minimum use of lipid excipients for the enhanced solubility, in vitro dissolution, lipase inhibition, and in vivo performance.…
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Keywords:
orlistat;
enhanced solubility;
orlistat loaded;
vivo performance ... See more keywords
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Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020363
Abstract: Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited…
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Keywords:
dissolution rate;
dissolution;
solubility dissolution;
bioavailability ... See more keywords
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Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020399
Abstract: The current study was designed to formulate ternary solid dispersions (TSDs) of dexibuprofen (Dex) by solvent evaporation to augment the solubility and dissolution profile, in turn providing gastric protection and effective anti-inflammatory activity. Initially, nine…
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Keywords:
solid dispersions;
formulation;
enhanced solubility;
dex ... See more keywords