Tumor Microenvironment-Triggered Aggregation of Antiphagocytosis 99m Tc-Labeled Fe3 O4 Nanoprobes for Enhanced Tumor Imaging In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced materials"
DOI: 10.1002/adma.201701095
Abstract: A tumor microenvironment responsive nanoprobe is developed for enhanced tumor imaging through in situ crosslinking of the Fe3 O4 nanoparticles modified with a responsive peptide sequence in which a tumor-specific Arg-Gly-Asp peptide for tumor targeting… read more here.
Keywords: tumor microenvironment; enhanced tumor; fe3; tumor imaging ... See more keywords
IR 780-loaded hyaluronic acid micelles for enhanced tumor-targeted photothermal therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.10.033
Abstract: In this study, we propose using IR 780-loaded, CD44-targeted hyaluronic acid-based micelles (HA-IR 780) for enhanced photothermal therapy (PTT) effects in tumors. Two kinds of HA-C18 micelles were synthesized from different C18 feed ratios with… read more here.
Keywords: 780 loaded; hyaluronic acid; enhanced tumor; photothermal therapy ... See more keywords
Combretastatin A4-combined photodynamic therapy for enhanced tumor therapeutic efficacy
Sign Up to like & getrecommendations! Published in 2021 at "Materials today communications"
DOI: 10.1016/j.mtcomm.2021.102616
Abstract: Abstract The limitation of traditional photodynamic therapy (PDT) such as the inherent hypoxia, the light penetration and the photosensitizer’s activity make it difficult to achieve a satisfactory therapeutic effect. To overcome these restrictions and enhance… read more here.
Keywords: therapy; efficacy; tumor; tpp nh2 ... See more keywords
Engineered nanomedicines with enhanced tumor penetration
Sign Up to like & getrecommendations! Published in 2019 at "Nano Today"
DOI: 10.1016/j.nantod.2019.100800
Abstract: Abstract Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is inefficient tumor penetration caused by specific tumor microenvironments,… read more here.
Keywords: tumor penetration; nanomedicines enhanced; engineered nanomedicines; enhanced tumor ... See more keywords
Acid-Directed Electrostatic Self-Assembly Generates Charge-Reversible Bacteria for Enhanced Tumor Targeting and Low Tissue Trapping.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c08684
Abstract: Despite recent preclinical progress with oncolytic bacteria in cancer therapy, dose-limiting toxicity has been a long-standing challenge for clinical application. Genetic and chemical modifications for enhancing the bacterial tumor-targeting ability have been unable to establish… read more here.
Keywords: self assembly; tumor targeting; tissue trapping; low tissue ... See more keywords
Enhanced Tumor Selectivity of 5-Fluorouracil Using a Reactive Oxygen Species-Activated Prodrug Approach.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00539
Abstract: We report the design, synthesis, and evaluation of novel 5-fluorouracil (5FU) prodrugs 1a,1b that are efficiently activated by the high level of reactive oxygen species (ROS) in cancer cells. Prodrugs 1a,1b selectively kill cancer cells… read more here.
Keywords: reactive oxygen; oxygen species; selectivity fluorouracil; tumor selectivity ... See more keywords
Self-Propelled Janus Nanocatalytic Robots Guided by Magnetic Resonance Imaging for Enhanced Tumor Penetration and Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12219
Abstract: Biomedical micro/nanorobots as active delivery systems with the features of self-propulsion and controllable navigation have made tremendous progress in disease therapy and diagnosis, detection, and biodetoxification. However, existing micro/nanorobots are still suffering from complex drug… read more here.
Keywords: tumor; therapy; tumor penetration; self propelled ... See more keywords
Stapling of short cell-penetrating peptides for enhanced tumor cell-and-tissue dual-penetration.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06595e
Abstract: Effective delivery of therapeutics to tumors is generally hampered by the limited penetration of biological barriers imposed by the tumor microenvironment. Despite the broad applications of cell-penetrating peptides (CPPs) for intracellular delivery of therapeutics across… read more here.
Keywords: cell; penetration; cell penetrating; penetrating peptides ... See more keywords
Amplification of ferroptosis with a liposomal nanoreactor cooperates with low-toxicity doxorubicin apoptosis for enhanced tumor chemotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00079b
Abstract: Despite the remarkable tumor inhibition effect of doxorubicin (DOX), its cardiotoxicity severely limits the clinical dosage and further impairs the chemotherapy efficacy. To improve the biosafety and effectiveness of conventional chemotherapy, we propose a strategy… read more here.
Keywords: apoptosis; doxorubicin; ferroptosis; chemotherapy ... See more keywords