Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202411735
Abstract: During the formation of kidney stones, the interaction between crystals and tubular epithelial cells (TECs) leads to tubular injury and dysfunction, which in turn promote stone formation. However, the molecular mechanisms underlying these changes in… read more here.
Keywords: calcium oxalate; caox crystal; deposition; enhancer ... See more keywords
NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer
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DOI: 10.1002/glia.23521
Abstract: NG2 is a type 1 integral membrane glycoprotein encoded by the Cspg4 gene. It is expressed on glial progenitor cells known as NG2 glial cells or oligodendrocyte precursor cells that exist widely throughout the developing… read more here.
Keywords: transcription; cspg4 gene; ng2 glia; ng2 ... See more keywords
Visualization of Enhancer-Derived Noncoding RNA.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-4035-6_3
Abstract: Enhancers are principal regulators that allow spatiotemporal tissue-specific control of gene expression. While mounting evidence suggests that enhancer-derived long noncoding RNAs (long ncRNAs), including enhancer RNAs (eRNAs), are an important component of enhancer function, their… read more here.
Keywords: visualization enhancer; noncoding rna; derived noncoding; biology ... See more keywords
Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7113-8_10
Abstract: Excessive deposition of extracellular matrix (ECM) is a common hallmark of fibrotic diseases in various organs. Chiefly among this ECM are collagen types I and III, secreted by local fibroblasts, and other mesenchymal cells recruited… read more here.
Keywords: characterization mesenchymal; fibroblast cells; mesenchymal fibroblast; promoter enhancer ... See more keywords
Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity
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DOI: 10.1007/s00018-018-2820-1
Abstract: Cancer heterogeneity arises during tumor progression as a consequence of genetic insults, environmental cues, and reversible changes in the epigenetic state, favoring tumor cell plasticity. The role of enhancer reprogramming is emerging as a relevant… read more here.
Keywords: cancer; enhancer; cell; tumor progression ... See more keywords
Genetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00763-8
Abstract: Mitogen-activated protein kinase-associated protein 1 (MAPKAP1) is a unique component of the mechanistic target of rapamycin (MTOR) pathway which plays a pivotal role in carcinogenesis. The role of enhancer variant in carcinogenesis receives increased attentions.… read more here.
Keywords: predisposition glioma; glioma; enhancer variant; mapkap1 ... See more keywords
A MGMT Enhancer Variant is Associated with Glioma Susceptibility and Progression
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DOI: 10.1007/s10571-025-01605-6
Abstract: The O6-methylguanine-DNA methyltransferase (MGMT) plays a significant role in the pathogenesis and progression of glioma. Numerous enhancer variants, including those within the MGMT gene region and adjacent gene regions, have been found to be associated… read more here.
Keywords: progression; enhancer; susceptibility progression; glioma susceptibility ... See more keywords
Pancreatic Islet Transcriptional Enhancers and Diabetes
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DOI: 10.1007/s11892-019-1230-6
Abstract: Common genetic variants that associate with type 2 diabetes risk are markedly enriched in pancreatic islet transcriptional enhancers. This review discusses current advances in the annotation of islet enhancer variants and their target genes. Recent… read more here.
Keywords: pancreatic islet; enhancers diabetes; transcriptional enhancers; islet ... See more keywords
LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription.
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DOI: 10.1016/j.celrep.2017.01.078
Abstract: MyoD is a master regulator of myogenesis. Chromatin modifications required to trigger MyoD expression are still poorly described. Here, we demonstrate that the histone demethylase LSD1/KDM1a is recruited on the MyoD core enhancer upon muscle… read more here.
Keywords: transcription; expression; myod expression; lsd1 ... See more keywords
Positive and Negative Control of Enhancer-Promoter Interactions by Other DNA Loops Generates Specificity and Tunability.
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DOI: 10.1016/j.celrep.2019.02.002
Abstract: Enhancers are ubiquitous and critical gene-regulatory elements. However, quantitative understanding of the role of DNA looping in the regulation of enhancer action and specificity is limited. We used the Escherichia coli NtrC enhancer-σ54 promoter system… read more here.
Keywords: positive negative; enhancer promoter; control; promoter ... See more keywords
Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor
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DOI: 10.1016/j.celrep.2020.107803
Abstract: SUMMARY The function of enhancer RNAs (eRNAs) in transcriptional regulation remains obscure. By analyzing the genome-wide nascent transcript profiles in breast cancer cells, we identify a special group of eRNAs that are essential for estrogen-induced… read more here.
Keywords: estrogen; rnas mediate; mediate estrogen; enhancer rnas ... See more keywords