Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
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DOI: 10.1038/s41467-021-21893-y
Abstract: Cell type-specific enhancers are activated by coordinated actions of lineage-determining transcription factors (LDTFs) and chromatin regulators. The SWI/SNF chromatin remodeling complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) are both implicated in enhancer activation.… read more here.
Keywords: type specific; baf mll4; mll4; enhancer activation ... See more keywords
PHF20 is crucial for epigenetic control of starvation-induced autophagy through enhancer activation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac584
Abstract: Abstract Autophagy is a catabolic pathway that maintains cellular homeostasis under various stress conditions, including conditions of nutrient deprivation. To elevate autophagic flux to a sufficient level under stress conditions, transcriptional activation of autophagy genes… read more here.
Keywords: enhancer activation; starvation; epigenetic control; activation ... See more keywords
Widespread enhancer activation via ERĪ± mediates estrogen response in vivo during uterine development
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DOI: 10.1093/nar/gky260
Abstract: Abstract Little is known regarding how steroid hormone exposures impact the epigenetic landscape in a living organism. Here, we took a global approach to understanding how exposure to the estrogenic chemical, diethylstilbestrol (DES), affects the… read more here.
Keywords: enhancer activation; uterine development; enhancer; widespread enhancer ... See more keywords
PAF1 regulation of promoter-proximal pause release via enhancer activation
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DOI: 10.1126/science.aan3269
Abstract: Multitalented enhancers Productive transcription from DNA demands initiation, elongation, and termination. Enhancers are DNA sequences that loop with promoters to initiate transcription. Chen et al. show that enhancers also regulate gene expression by modulating transcription… read more here.
Keywords: promoter proximal; release paused; enhancer activation; paf1 ... See more keywords