GRADED PU.1 LEVELS ACTIVATE GRANULOCYTE VS. MACROPHAGE GENES VIA MULTIPLE (SUPER)ENHANCER ELEMENTS
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.422
Abstract: Precise levels of transcription factor PU.1 are critical for differentiation to distinct blood lineages, and even modest decreases leads to leukemogenesis. However, the mechanism of how target genes sense different PU.1 levels is unknown. To… read more here.
Keywords: levels activate; activity; graded levels; enhancer ... See more keywords
Expression of type II collagen and aggrecan genes is regulated through distinct epigenetic modifications of their multiple enhancer elements.
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DOI: 10.1016/j.gene.2019.04.034
Abstract: To maintain normal function of cartilage tissue normally, the presence of a sufficient amount of type II collagen and aggrecan is essential, and their synthesis is tightly regulated. Therefore, understanding the mechanisms that control the… read more here.
Keywords: collagen; collagen aggrecan; enhancer elements; expression ... See more keywords
Genome-wide identification of enhancer elements in the placenta.
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DOI: 10.1016/j.placenta.2018.09.003
Abstract: Normal placental development is essential for a healthy pregnancy, and is contingent upon tight spatiotemporal regulation of gene expression. One level of transcriptional control is via enhancer elements in the genome. Enhancers are distal cis-regulatory… read more here.
Keywords: genome wide; placenta genome; gene expression; enhancer elements ... See more keywords
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
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DOI: 10.1038/s41467-019-11672-1
Abstract: Transcription factor networks shape the gene expression programs responsible for normal cell identity and pathogenic state. Using Core Regulatory Circuitry analysis (CRC), we identify PAX8 as a candidate oncogene in Renal Cell Carcinoma (RCC) cells.… read more here.
Keywords: renal cell; pax8; cell carcinoma; enhancer elements ... See more keywords
Identification and Characterisation of Putative Enhancer Elements in Mouse Embryonic Stem Cells
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DOI: 10.1177/1177932220974623
Abstract: Enhancer elements control mammalian transcription largely in a cell-type-specific manner. The genome-wide identification of enhancer elements and their activity status in a cellular context is therefore fundamental to understanding cell identity and function. We determined… read more here.
Keywords: enhancer elements; mouse embryonic; h3k4me1; identification ... See more keywords