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   Articles with "enhancer hijacking" as a keyword



Modelling and drug targeting of a myeloid neoplasm with atypical 3q26/MECOM rearrangement using patient‐specific iPSCs

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recommendations! Published in 2024 at "British Journal of Haematology"

DOI: 10.1111/bjh.19720

Abstract: Structural variations involving enhancer hijacking induce aberrant oncogene expression and cause tumorigenesis. A rare translocation, t(3;8)(q26.2;q24), is associated with MECOM and MYC rearrangement, causing myeloid neoplasms with a dismal prognosis. The most recent World Health… read more here.

Keywords: drug; mecom; mecom rearrangement; enhancer hijacking ... See more keywords

Abstract 6625: LinkPrep™ - a comprehensive assay for cancer genome characterization - enabling structural variant detection and discovery of enhancer hijacking

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-6625

Abstract: Cancer arises from genetic and/or epigenetic disruptions. Currently, no single technology can capture the full range of variation that drives tumorigenesis with high sensitivity. Furthermore, epigenetic changes resulting from somatic variation remain poorly understood. The… read more here.

Keywords: detection; cancer; linkprep; cancer genome ... See more keywords

Abstract IA03: Subgroup-specific enhancer hijacking in medulloblastoma

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recommendations! Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.pedca17-ia03

Abstract: In recent years, next-generation sequencing has uncovered the spectrum of driver genes and molecular processes contributing to most cancer entities, including pediatric cancer. This holds true for medulloblastoma (MB), the most common malignant childhood brain… read more here.

Keywords: subgroup specific; medulloblastoma; enhancer hijacking; cancer ... See more keywords

Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription.

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recommendations! Published in 2022 at "Blood"

DOI: 10.1182/blood-2022-169565

Abstract: Structural variants (SVs) involving enhancer hijacking can rewire chromatin topologies to cause oncogene activation in human cancers including hematologic malignancies; however, due to the lack of tools to assess their effects on gene regulation and… read more here.

Keywords: transcription; enhancer hijacking; chromatin; structural variation ... See more keywords