Systematic Functional Interrogation of Genes in GWAS Loci Identified ATF1 as a Key Driver in Colorectal Cancer Modulated by a Promoter-Enhancer Interaction.
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DOI: 10.1016/j.ajhg.2019.05.004
Abstract: Genome-wide association studies (GWASs) have identified approximately 100 colorectal cancer (CRC) risk loci. However, the causal genes in these loci have not been systematically interrogated. We conducted a high-throughput RNA-interference functional screen to identify the… read more here.
Keywords: risk; enhancer interaction; interaction; promoter enhancer ... See more keywords