HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.08.018
Abstract: Aberrant expression of HOXA9 is a prominent feature of acute leukemia driven by diverse oncogenes. Here we show that HOXA9 overexpression in myeloid and B progenitor cells leads to significant enhancer reorganizations with prominent emergence… read more here.
Keywords: novo enhancers; leukemogenesis; hoxa9 reprograms; hoxa9 ... See more keywords
MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping
Sign Up to like & getrecommendations! Published in 2017 at "Nature immunology"
DOI: 10.1038/ni.3812
Abstract: MLL4 is an essential subunit of the histone H3 Lys4 (H3K4)-methylation complexes. We found that MLL4 deficiency compromised the development of regulatory T cells (Treg cells) and resulted in a substantial decrease in monomethylated H3K4… read more here.
Keywords: via chromatin; chromatin; chromatin looping; mll4 ... See more keywords
eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.05.11.491502
Abstract: Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring… read more here.
Keywords: uncovers enhancer; oesophageal adenocarcinoma; profiling uncovers; enhancer landscape ... See more keywords