Positive and Negative Control of Enhancer-Promoter Interactions by Other DNA Loops Generates Specificity and Tunability.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.02.002
Abstract: Enhancers are ubiquitous and critical gene-regulatory elements. However, quantitative understanding of the role of DNA looping in the regulation of enhancer action and specificity is limited. We used the Escherichia coli NtrC enhancer-σ54 promoter system… read more here.
Keywords: positive negative; enhancer promoter; control; promoter ... See more keywords
Regulatory Landscaping: How Enhancer-Promoter Communication Is Sculpted in 3D.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.05.032
Abstract: During embryogenesis, precise gene transcription in space and time requires that distal enhancers and promoters communicate by physical proximity within gene regulatory landscapes. To achieve this, regulatory landscapes fold in nuclear space, creating complex 3D… read more here.
Keywords: promoter communication; regulatory landscapes; enhancer promoter; promoter ... See more keywords
Keep Them Close: PRC2 Poises Enhancer-Promoter Interactions at Anterior Neuronal Genes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.04.006
Abstract: Enhancers exist in different epigenetic states: active, primed, or poised. However, it is not yet understood how the different enhancer states influence gene activation. In this issue of Cell Stem Cell, Cruz-Molina et al. (2017) unravel… read more here.
Keywords: enhancer promoter; close prc2; prc2 poises; poises enhancer ... See more keywords
Gene regulation: The nuclear pore — a scaffold for inducible genes
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Genetics"
DOI: 10.1038/nrg.2017.29
Abstract: G etty The nuclear pore complex (NPC) is known to directly interact with chromatin and to influence transcription, but the mechanistic roles of its subunits in regulating gene expression were unclear. Pascual-Garcia et al. now… read more here.
Keywords: inducible genes; gene; enhancer promoter; nuclear pore ... See more keywords
Gene expression: The yin and yang of enhancer–promoter interactions
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2017.136
Abstract: The transcription factor YY1 structurally mediates enhancer–promoter looping interactions and controls gene expression. read more here.
Keywords: expression yin; enhancer promoter; gene expression;
Enhancer–promoter entanglement explains their transcriptional interdependence
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216436120
Abstract: Significance Transcription at the enhancer and target promoter is highly coordinated, but it is unclear why. Using unique cell-free assays, here we were able to demonstrate that transcription at the enhancer and target promoter is… read more here.
Keywords: promoter; transcription enhancer; interdependence; enhancer promoter ... See more keywords
BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer–promoter activity and maintains pluripotency
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab034
Abstract: Abstract Maintenance of stem-cell identity requires proper regulation of enhancer activity. Both transcription factors OCT4/SOX2/NANOG and histone methyltransferase complexes MLL/SET1 were shown to regulate enhancer activity, but how they are regulated in embryonic stem cells… read more here.
Keywords: enhancer promoter; set1 complexes; maintains pluripotency; mll set1 ... See more keywords
spatzie: an R package for identifying significant transcription factor motif co-enrichment from enhancer-promoter interactions.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkac036
Abstract: Genomic interactions provide important context to our understanding of the state of the genome. One question is whether specific transcription factor interactions give rise to genome organization. We introduce spatzie, an R package and a… read more here.
Keywords: enhancer promoter; transcription factor; transcription; spatzie package ... See more keywords
NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution.
Sign Up to like & getrecommendations! Published in 2022 at "Genome research"
DOI: 10.1101/gr.275986.121
Abstract: Enhancer-promoter communication is known to regulate spatiotemporal dynamics of gene expression. Several methods are available to capture enhancer-promoter interactions, but they either require large amounts of starting materials and are costly, or provide a relative… read more here.
Keywords: enhancer promoter; high resolution; chromatin; open chromatin ... See more keywords
Risk SNP-Mediated Enhancer–Promoter Interaction Drives Colorectal Cancer through Both FADS2 and AP002754.2
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-2389
Abstract: This study provides an oncogenic regulatory circuit among several oncogenes including E2F1, FADS2, and AP002754.2 underlying the association of rs174575 with the colorectal cancer risk, which is driven by long-range enhancer-promoter interaction loops. Although genome-wide… read more here.
Keywords: fads2; cancer; risk; enhancer promoter ... See more keywords
YY1 Facilitates Enhancer-Promoter Contacts to Promote Gene Expression.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-233
Abstract: YY1 preferentially occupies active enhancers and promoters and forms dimers to promote DNA looping. read more here.
Keywords: enhancer promoter; contacts promote; promoter contacts; promote gene ... See more keywords