The landscape of enhancer RNA identify prognosisârelated molecular subtypes in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4959
Abstract: Enhancer RNAs (eRNAs), the transcriptional products of active enhancers, are of great significance in the initial progression of cancers. However, the biological function and bioinformatics profiles of eRNA in gastric cancer remains largely enigmatic. read more here.
Keywords: identify prognosis; rna identify; gastric cancer; landscape enhancer ... See more keywords
Enhancer Rna's In Brain Function and Disease
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.139
Abstract: Abstract Distal enhancer elements in DNA enable higher-order chromatin interactions that regulate gene expression programs critical for cellular development, phenotype, and function. The vast majority of genetic variants linked to human health and disease by… read more here.
Keywords: enhancer rna; disease; brain function; expression ... See more keywords
Enhancer RNA: biogenesis, function, and regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Essays in biochemistry"
DOI: 10.1042/ebc20200014
Abstract: Enhancers are noncoding DNA elements that are present upstream or downstream of a gene to control its spatial and temporal expression. Specific histone modifications, such as monomethylation on histone H3 lysine 4 (H3K4me1) and H3K27ac,… read more here.
Keywords: function; rna biogenesis; enhancer rna; enhancer ... See more keywords
Abstract 4913: Enhancer RNA profiles predict sensitivity to a novel GPX4 inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4913
Abstract: Inhibition of the GPX4 enzyme leads to the rapid accumulation of toxic lipid peroxides and cell death through a process known as ferroptosis. This mechanism has recently garnered significant attention in the field of oncology… read more here.
Keywords: cell; sensitivity; rna profiles; enhancer rna ... See more keywords
GAS1RR, an immune-related enhancer RNA, is related to biochemical recurrence-free survival in prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221131888
Abstract: Prostate cancer (PCa) is one of the malignant tumors of urinary system with a high morbidity. Enhancer RNA is a subclass of long non-coding RNA transcribed from active enhancer regions, which plays a critical role… read more here.
Keywords: enhancer rna; free survival; gas1rr; cancer ... See more keywords
310-OR: Integrating Islet and Skeletal Muscle Enhancer RNA Signatures with Diverse Omics Data Enables Fine-Mapping of Diabetes and Related Trait GWAS Loci
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-310-or
Abstract: Type 2 diabetes (T2D) results from interaction between genetic variation and environmental exposures that influence insulin secretion in pancreatic islets and insulin resistance in skeletal muscle and other peripheral tissues. Genome-wide association studies (GWAS) have… read more here.
Keywords: skeletal muscle; enhancer rna; cage; gwas ... See more keywords
Identification of a Putative Enhancer RNA for EGFR in Hyper-Accessible Regions in Esophageal Squamous Cell Carcinoma Cells by Analysis of Chromatin Accessibility Landscapes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.724687
Abstract: Abnormal genetic and epigenetic modifications play a key role in esophageal cancer. By Assay for Transposase-Accessible Chromatin by sequencing (ATAC-seq), this study compared chromatin accessibility landscapes among two esophageal squamous cell carcinoma (ESCC) cell lines,… read more here.
Keywords: enhancer rna; analysis; hyper accessible; accessible regions ... See more keywords
Enhancer RNA LINC00242-Induced Expression of PHF10 Drives a Better Prognosis in Pancreatic Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.795090
Abstract: Enhancer RNA is a kind of non-coding RNA, which is transcribed from the enhancer region of gene and plays an important role in gene transcription regulation. However, the role of eRNA in pancreatic adenocarcinoma (PAAD)… read more here.
Keywords: expression; enhancer rna; gene; target ... See more keywords
Enhancer RNA-based modeling of adverse events and objective responses of cancer immunotherapy reveals associated key enhancers and target genes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1048127
Abstract: Immune checkpoint inhibitors (ICI) targeting PD-1/PD-L1 or CTLA-4 are emerging and effective immunotherapy strategies. However, ICI-treated patients present heterogeneous responses and adverse events, thus demanding effective ways to assess benefit over risk before treatment. Here,… read more here.
Keywords: enhancers target; target genes; immunotherapy; enhancer rna ... See more keywords
Enhancer RNA (eRNA) in Human Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911582
Abstract: Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs… read more here.
Keywords: human diseases; enhancer rna; rna erna; erna human ... See more keywords
Functional roles of antisense enhancer RNA for promoting prostate cancer progression
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.51931
Abstract: Rationale: Enhancer RNA (eRNA) bi-directionally expresses from enhancer region and sense eRNA regulates adjacent mRNA in cis and in trans. However, it has remained unclear whether antisense eRNAs in different direction are functional or merely… read more here.
Keywords: cancer; antisense erna; enhancer rna; prostate cancer ... See more keywords