Knockdown of Nuclear-Located Enhancer RNAs and Long ncRNAs Using Locked Nucleic Acid GapmeRs.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-4035-6_2
Abstract: The human genome is widely transcribed outside of protein-coding genes, producing thousands of noncoding RNAs from different subfamilies including enhancer RNAs. Functional studies to determine the role of individual genes are challenging with noncoding RNAs… read more here.
Keywords: locked nucleic; knockdown nuclear; noncoding rnas; enhancer rnas ... See more keywords
Enhancer RNAs: a missing regulatory layer in gene transcription
Sign Up to like & getrecommendations! Published in 2017 at "Science China Life Sciences"
DOI: 10.1007/s11427-017-9370-9
Abstract: Enhancers and super-enhancers exert indispensable roles in maintaining cell identity through spatiotemporally regulating gene transcription. Meanwhile, active enhancers and super-enhancers also produce transcripts termed enhancer RNAs (eRNAs) from their DNA elements. Although enhancers have been… read more here.
Keywords: transcription; gene transcription; rnas missing; enhancer rnas ... See more keywords
Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERĪ± and Its Cofactor
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107803
Abstract: SUMMARY The function of enhancer RNAs (eRNAs) in transcriptional regulation remains obscure. By analyzing the genome-wide nascent transcript profiles in breast cancer cells, we identify a special group of eRNAs that are essential for estrogen-induced… read more here.
Keywords: estrogen; rnas mediate; mediate estrogen; enhancer rnas ... See more keywords
Divergent Transcription of the Nkx2-5 Locus Generates Two Enhancer RNAs with Opposing Functions
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101539
Abstract: Summary Enhancer RNAs (eRNAs) are a subset of long noncoding RNA generated from genomic enhancers: they are thought to act as potent promoters of the expression of nearby genes through interaction with the transcriptional and… read more here.
Keywords: divergent transcription; transcription; enhancer rnas; transcription nkx2 ... See more keywords
Spirits in the Material World: Enhancer RNAs in Transcriptional Regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2020.08.007
Abstract: Responses to developmental and environmental cues depend on precise spatiotemporal control of gene transcription. Enhancers, which comprise DNA elements bound by regulatory proteins, can activate target genes in response to these external signals. Recent studies… read more here.
Keywords: world enhancer; spirits material; material world; enhancer rnas ... See more keywords
Enhancer RNAs in cancer: regulation, mechanisms and therapeutic potential
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DOI: 10.1080/15476286.2020.1712895
Abstract: ABSTRACT Enhancers are distal genomic elements critical for gene regulation and cell identify control during development and diseases. Many human cancers were found to associate with enhancer malfunction, due to genetic and epigenetic alterations, which… read more here.
Keywords: gene regulation; rnas cancer; cancer; enhancer rnas ... See more keywords
Comprehensive Analysis of Enhancer RNAs Identifies LINC00689 and ELFN1-AS1 as Novel Prognostic Biomarkers in Uveal Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/5994800
Abstract: Enhancer RNAs (eRNAs) have emerged as key players in the pathology of several tumors, including uveal melanoma. Here, we aimed to explore the prognostic values of eRNAs in uveal melanoma (UVM) patients. The expressing data… read more here.
Keywords: linc00689 elfn1; uvm patients; enhancer rnas; elfn1 as1 ... See more keywords
Profiling of Androgen-Dependent Enhancer RNAs Expression in Human Prostate Tumors: Search for Malignancy Transition Markers
Sign Up to like & getrecommendations! Published in 2021 at "Research and Reports in Urology"
DOI: 10.2147/rru.s328661
Abstract: Introduction Although the ability of androgens to promote prostate cancer development has been known for decades, the molecular mechanisms of androgen receptor (AR) signaling in the tumorigenesis remain unclear. Enhancer RNAs (eRNAs) transcribed from strong… read more here.
Keywords: expression; androgen dependent; prostate; enhancer rnas ... See more keywords
A Novel and Robust Prognostic Model for Hepatocellular Carcinoma Based on Enhancer RNAs-Regulated Genes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.849242
Abstract: Evidence has demonstrated that enhancer RNAs (eRNAs) play a vital role in the progression and prognosis of cancers, but few studies have focused on the prognostic ability of eRNA-regulated genes (eRGs) for hepatocellular carcinoma (HCC).… read more here.
Keywords: hepatocellular carcinoma; enhancer rnas; robust prognostic; regulated genes ... See more keywords
Enhancer RNAs (eRNAs) in Cancer: The Jacks of All Trades
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14081978
Abstract: Simple Summary This review focuses on eRNAs and the several mechanisms by which they can regulate gene expression. In particular we describe here the most recent examples of eRNAs dysregulated in cancer or involved in… read more here.
Keywords: enhancer rnas; cancer jacks; jacks trades; rnas ernas ... See more keywords
Emerging Role of Enhancer RNAs as Potential Diagnostic and Prognostic Biomarkers in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Non-Coding RNA"
DOI: 10.3390/ncrna8050066
Abstract: Enhancers are distal cis-acting elements that are commonly recognized to regulate gene expression via cooperation with promoters. Along with regulating gene expression, enhancers can be transcribed and generate a class of non-coding RNAs called enhancer… read more here.
Keywords: enhancer rnas; role; rnas potential; role enhancer ... See more keywords