The impact of the CYP2D6 "enhancer" single nucleotide polymorphism on CYP2D6 activity.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2469
Abstract: rs5758550 has been associated with enhanced transcription and suggested to be a useful marker of CYP2D6 activity. As there are limited and inconsistent data regarding the utility of this distant "enhancer" single nucleotide polymorphism (SNP),… read more here.
Keywords: cyp2d6; enhancer snp; cyp2d6 activity; impact cyp2d6 ... See more keywords
Long-Distance Phasing of a Tentative “Enhancer” Single-Nucleotide Polymorphism With CYP2D6 Star Allele Definitions
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00486
Abstract: Background The CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements.… read more here.
Keywords: cyp2d6; enhancer snp; star; cyp2d6 activity ... See more keywords