Cohesin occupancy and composition at enhancers and promoters are linked to DNA replication origin proximity in Drosophila.
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DOI: 10.1101/gr.243832.118
Abstract: Cohesin consists of the SMC1-SMC3-Rad21 tripartite ring and the SA protein that interacts with Rad21. The Nipped-B protein loads cohesin topologically around chromosomes to mediate sister chromatid cohesion and facilitate long-range control of gene transcription.… read more here.
Keywords: drosophila; sister chromatid; cohesin; dna replication ... See more keywords
Sequence Characteristics Distinguish Transcribed Enhancers from Promoters and Predict Their Breadth of Activity
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DOI: 10.1534/genetics.118.301895
Abstract: Enhancers and promoters both regulate gene expression by recruiting transcription factors (TFs); however, the degree to which enhancer vs. promoter activity is due to differences in their sequences or to genomic context is the subject… read more here.
Keywords: transcribed enhancers; activity; enhancers promoters; promoter ... See more keywords
Roles of Polycomb Complexes in the Reconstruction of 3D Genome Architecture during Preimplantation Embryonic Development
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DOI: 10.3390/genes13122382
Abstract: The appropriate deployment of developmental programs depends on complex genetic information encoded by genomic DNA sequences and their positioning and contacts in the three-dimensional (3D) space within the nucleus. Current studies using novel techniques including,… read more here.
Keywords: developmental programs; pcg; pcg complexes; roles polycomb ... See more keywords