GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma.
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DOI: 10.1016/j.canlet.2017.09.021
Abstract: New targeted therapies are urgently needed to improve the survival of patients with refractory osteosarcoma (OS). In this study, we show that bortezomib (BTZ), not for OS treatment in the clinic, induces endoplasmic reticulum (ER)… read more here.
Keywords: enhances atf4; atf4 induced; inhibition enhances; grp78 inhibition ... See more keywords