The WW1 domain enhances auto-inhibition in Smurf ubiquitin ligases.
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DOI: 10.1016/j.jmb.2019.09.018
Abstract: Down-regulation of ubiquitin (Ub) ligase activity prevents premature ubiquitination and is critical for cellular homeostasis. Nedd4 Ub ligases share a common domain architecture and yet are regulated in distinct ways through interactions of the catalytic… read more here.
Keywords: domain enhances; hect domain; inhibition; enhances auto ... See more keywords