Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours
Sign Up to like & getrecommendations! Published in 2019 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-019-0375-6
Abstract: Checkpoint blockade therapy targeting the programmed-death ligand 1 (PD-L1) and its receptor programmed cell death 1 promotes T-cell-mediated immunosurveillance against tumours, and has been associated with marked clinical benefit in cancer patients. Antibodies against PD-L1… read more here.
Keywords: palmitoylation; enhances cell; inhibiting palmitoylation; palmitoylation enhances ... See more keywords
Augmenter of liver regeneration enhances cell proliferation through the microRNA‐26a/Akt/cyclin D1 pathway in hepatic cells
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology Research"
DOI: 10.1111/hepr.13404
Abstract: Hepatocytes can proliferate and regenerate when injured by toxins, viral infections, and so on. Augmenter of liver regeneration (ALR) is a key regulator of liver regeneration, but the mechanism is unknown. The role of ALR… read more here.
Keywords: augmenter liver; enhances cell; cell proliferation; liver regeneration ... See more keywords
Venetoclax enhances T cell-mediated anti-leukemic activity by increasing ROS production.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020009081
Abstract: Venetoclax, a Bcl-2 inhibitor, in combination with the hypomethylating agent, Azacytidine, achieves complete response with or without count recovery in approximately 70% of treatment-naïve elderly patients unfit for conventional intensive chemotherapy. However, the mechanism of… read more here.
Keywords: venetoclax; cell mediated; enhances cell; venetoclax enhances ... See more keywords
DOC2b Enhances β-Cell Function Via A Novel Tyrosine Phosphorylation-Dependent Mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-0681
Abstract: Double C2 Domain Β (DOC2b) protein is required for glucose-stimulated insulin secretion (GSIS) in β-cells, the underlying mechanism of which remains unresolved. Our biochemical analysis using primary human islets, human and rodent clonal β-cells revealed… read more here.
Keywords: doc2b; gsis; enhances cell; mechanism ... See more keywords