Metformin enhances cisplatin induced inhibition of cholangiocarcinoma cells via AMPK‐mTOR pathway
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DOI: 10.1016/j.lfs.2018.05.046
Abstract: Aims: AMP‐activated protein kinase (AMPK) functions as a cellular energy sensor regulating various aspects of cellular metabolism. Metformin (Met), an activator of AMPK, has been reported to reduce the cancer risk and enhance antitumor effects… read more here.
Keywords: enhances cisplatin; effect; expression; metformin enhances ... See more keywords
Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis
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DOI: 10.1111/cpr.12474
Abstract: We previously demonstrated the roflumilast inhibited cell proliferation and increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of roflumilast in development of cisplatin (DDP)‐sensitive and ‐resistant ovarian cancer. read more here.
Keywords: cisplatin sensitivity; enhances cisplatin; roflumilast enhances; ovarian cancer ... See more keywords