mTOR inhibition enhances efficacy of dasatinib in ABL-rearranged Ph-like B-ALL
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DOI: 10.18632/oncotarget.24020
Abstract: High-risk subtypes of B-cell acute lymphoblastic leukemia (B-ALL) include Philadelphia chromosome-positive (Ph+) B-ALL driven by the BCR-ABL1 oncogene and a more recently identified subtype known as BCR-ABL-like or Ph-like B-ALL. A hallmark of both Ph+… read more here.
Keywords: enhances efficacy; mtor inhibition; dasatinib; inhibition enhances ... See more keywords
Knockdown of lncRNA TP53TG1 Enhances the Efficacy of Sorafenib in Human Hepatocellular Carcinoma Cells
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DOI: 10.3390/ncrna8040061
Abstract: The multikinase inhibitor, sorafenib, is a first-line treatment for hepatocellular carcinoma (HCC), but its limited efficacy, drug resistance and toxicity are a concern. In this study, we investigated the role of lncRNA TP53TG1 in the… read more here.
Keywords: hepatocellular carcinoma; hcc; efficacy sorafenib; lncrna tp53tg1 ... See more keywords
Atorvastatin Enhances the Efficacy of Immune Checkpoint Therapy and Suppresses the Cellular and Extracellular Vesicle PD-L1
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14081660
Abstract: According to clinical studies, statins improve the efficacy of programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) blockade therapy for breast cancer; however, the underlying mechanisms are unclear. Herein, we showed that atorvastatin (ATO) decreased the content of… read more here.
Keywords: atorvastatin enhances; ato; therapy; efficacy ... See more keywords